Innate immune recognition of breast tumor cells mediates CCL22 secretion favoring Treg recruitment within tumor environment

Regulatory T cells (Treg) have been reported of poor prognosis for overall survival in primary breast tumors (BT). As CCL22 plays a major role in Treg recruitment within primary BT we deciphered the mechanisms involved in the CCL22 production by breast epithelial tumor cells and propose herein the m...

Descripción completa

Detalles Bibliográficos
Autores principales: Ménétrier-Caux, Christine, Faget, Julien, Biota, Cathy, Gobert, Michael, Blay, Jean-Yves, Caux, Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429586/
https://www.ncbi.nlm.nih.gov/pubmed/22934274
http://dx.doi.org/10.4161/onci.19680
_version_ 1782241823243108352
author Ménétrier-Caux, Christine
Faget, Julien
Biota, Cathy
Gobert, Michael
Blay, Jean-Yves
Caux, Christophe
author_facet Ménétrier-Caux, Christine
Faget, Julien
Biota, Cathy
Gobert, Michael
Blay, Jean-Yves
Caux, Christophe
author_sort Ménétrier-Caux, Christine
collection PubMed
description Regulatory T cells (Treg) have been reported of poor prognosis for overall survival in primary breast tumors (BT). As CCL22 plays a major role in Treg recruitment within primary BT we deciphered the mechanisms involved in the CCL22 production by breast epithelial tumor cells and propose herein the major role of their innate immune recognition in this production.
format Online
Article
Text
id pubmed-3429586
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Landes Bioscience
record_format MEDLINE/PubMed
spelling pubmed-34295862012-08-29 Innate immune recognition of breast tumor cells mediates CCL22 secretion favoring Treg recruitment within tumor environment Ménétrier-Caux, Christine Faget, Julien Biota, Cathy Gobert, Michael Blay, Jean-Yves Caux, Christophe Oncoimmunology Author's View Regulatory T cells (Treg) have been reported of poor prognosis for overall survival in primary breast tumors (BT). As CCL22 plays a major role in Treg recruitment within primary BT we deciphered the mechanisms involved in the CCL22 production by breast epithelial tumor cells and propose herein the major role of their innate immune recognition in this production. Landes Bioscience 2012-08-01 /pmc/articles/PMC3429586/ /pubmed/22934274 http://dx.doi.org/10.4161/onci.19680 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Ménétrier-Caux, Christine
Faget, Julien
Biota, Cathy
Gobert, Michael
Blay, Jean-Yves
Caux, Christophe
Innate immune recognition of breast tumor cells mediates CCL22 secretion favoring Treg recruitment within tumor environment
title Innate immune recognition of breast tumor cells mediates CCL22 secretion favoring Treg recruitment within tumor environment
title_full Innate immune recognition of breast tumor cells mediates CCL22 secretion favoring Treg recruitment within tumor environment
title_fullStr Innate immune recognition of breast tumor cells mediates CCL22 secretion favoring Treg recruitment within tumor environment
title_full_unstemmed Innate immune recognition of breast tumor cells mediates CCL22 secretion favoring Treg recruitment within tumor environment
title_short Innate immune recognition of breast tumor cells mediates CCL22 secretion favoring Treg recruitment within tumor environment
title_sort innate immune recognition of breast tumor cells mediates ccl22 secretion favoring treg recruitment within tumor environment
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429586/
https://www.ncbi.nlm.nih.gov/pubmed/22934274
http://dx.doi.org/10.4161/onci.19680
work_keys_str_mv AT menetriercauxchristine innateimmunerecognitionofbreasttumorcellsmediatesccl22secretionfavoringtregrecruitmentwithintumorenvironment
AT fagetjulien innateimmunerecognitionofbreasttumorcellsmediatesccl22secretionfavoringtregrecruitmentwithintumorenvironment
AT biotacathy innateimmunerecognitionofbreasttumorcellsmediatesccl22secretionfavoringtregrecruitmentwithintumorenvironment
AT gobertmichael innateimmunerecognitionofbreasttumorcellsmediatesccl22secretionfavoringtregrecruitmentwithintumorenvironment
AT blayjeanyves innateimmunerecognitionofbreasttumorcellsmediatesccl22secretionfavoringtregrecruitmentwithintumorenvironment
AT cauxchristophe innateimmunerecognitionofbreasttumorcellsmediatesccl22secretionfavoringtregrecruitmentwithintumorenvironment

Ejemplares similares