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Key role of the positive feedback between PGE(2) and COX2 in the biology of myeloid-derived suppressor cells
PGE(2) is the key factor needed for MDSCs development, accumulation and functional stability. PGE(2) initiates an EP2/EP4-mediated positive feedback between COX2 and PGE(2) in monocytic precursors, redirecting dendritic cell differentiation to MDSCs. COX2- or EP2/EP4- blockade abrogates MDSC functio...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Landes Bioscience
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429587/ https://www.ncbi.nlm.nih.gov/pubmed/22934275 http://dx.doi.org/10.4161/onci.19681 |