Key role of the positive feedback between PGE(2) and COX2 in the biology of myeloid-derived suppressor cells

PGE(2) is the key factor needed for MDSCs development, accumulation and functional stability. PGE(2) initiates an EP2/EP4-mediated positive feedback between COX2 and PGE(2) in monocytic precursors, redirecting dendritic cell differentiation to MDSCs. COX2- or EP2/EP4- blockade abrogates MDSC functio...

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Detalles Bibliográficos
Autores principales: Obermajer, Nataŝa, Kalinski, Pawel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429587/
https://www.ncbi.nlm.nih.gov/pubmed/22934275
http://dx.doi.org/10.4161/onci.19681
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author Obermajer, Nataŝa
Kalinski, Pawel
author_facet Obermajer, Nataŝa
Kalinski, Pawel
author_sort Obermajer, Nataŝa
collection PubMed
description PGE(2) is the key factor needed for MDSCs development, accumulation and functional stability. PGE(2) initiates an EP2/EP4-mediated positive feedback between COX2 and PGE(2) in monocytic precursors, redirecting dendritic cell differentiation to MDSCs. COX2- or EP2/EP4- blockade abrogates MDSC functions and their CXCR4-CXCL12-mediated attraction to cancer environment, providing convenient immunotherapeutic targets.
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spelling pubmed-34295872012-08-29 Key role of the positive feedback between PGE(2) and COX2 in the biology of myeloid-derived suppressor cells Obermajer, Nataŝa Kalinski, Pawel Oncoimmunology Author's View PGE(2) is the key factor needed for MDSCs development, accumulation and functional stability. PGE(2) initiates an EP2/EP4-mediated positive feedback between COX2 and PGE(2) in monocytic precursors, redirecting dendritic cell differentiation to MDSCs. COX2- or EP2/EP4- blockade abrogates MDSC functions and their CXCR4-CXCL12-mediated attraction to cancer environment, providing convenient immunotherapeutic targets. Landes Bioscience 2012-08-01 /pmc/articles/PMC3429587/ /pubmed/22934275 http://dx.doi.org/10.4161/onci.19681 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Obermajer, Nataŝa
Kalinski, Pawel
Key role of the positive feedback between PGE(2) and COX2 in the biology of myeloid-derived suppressor cells
title Key role of the positive feedback between PGE(2) and COX2 in the biology of myeloid-derived suppressor cells
title_full Key role of the positive feedback between PGE(2) and COX2 in the biology of myeloid-derived suppressor cells
title_fullStr Key role of the positive feedback between PGE(2) and COX2 in the biology of myeloid-derived suppressor cells
title_full_unstemmed Key role of the positive feedback between PGE(2) and COX2 in the biology of myeloid-derived suppressor cells
title_short Key role of the positive feedback between PGE(2) and COX2 in the biology of myeloid-derived suppressor cells
title_sort key role of the positive feedback between pge(2) and cox2 in the biology of myeloid-derived suppressor cells
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429587/
https://www.ncbi.nlm.nih.gov/pubmed/22934275
http://dx.doi.org/10.4161/onci.19681
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