Targeting the tumor mutanome for personalized vaccination therapy

Next generation sequencing enables identification of immunogenic tumor mutations targetable by individualized vaccines. In the B16F10 melanoma system as pre-clinical proof-of-concept model, we found a total of 563 non-synonymous expressed somatic mutations. Of the mutations we tested, one third were...

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Detalles Bibliográficos
Autores principales: Kreiter, Sebastian, Castle, John C., Türeci, Özlem, Sahin, Ugur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429589/
https://www.ncbi.nlm.nih.gov/pubmed/22934277
http://dx.doi.org/10.4161/onci.19727

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429589/
https://www.ncbi.nlm.nih.gov/pubmed/22934277
http://dx.doi.org/10.4161/onci.19727

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