Antagonizing the innate pattern recognition receptor CD204 to improve dendritic cell-targeted cancer immunotherapy

Extensive studies have established a role of scavenger receptor CD204 in pattern recognition and ligand uptake. Strikingly, we recently revealed a previously unrecognized feature of CD204 action in attenuating T-cell activation and antitumor immunity. Blocking its activity in dendritic cells represe...

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Detalles Bibliográficos
Autores principales: Yu, Xiaofei, Wang, Xiang-Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429590/
https://www.ncbi.nlm.nih.gov/pubmed/22934278
http://dx.doi.org/10.4161/onci.19728
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author Yu, Xiaofei
Wang, Xiang-Yang
author_facet Yu, Xiaofei
Wang, Xiang-Yang
author_sort Yu, Xiaofei
collection PubMed
description Extensive studies have established a role of scavenger receptor CD204 in pattern recognition and ligand uptake. Strikingly, we recently revealed a previously unrecognized feature of CD204 action in attenuating T-cell activation and antitumor immunity. Blocking its activity in dendritic cells represents a promising approach to the improvement of cancer immunotherapy.
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spelling pubmed-34295902012-08-29 Antagonizing the innate pattern recognition receptor CD204 to improve dendritic cell-targeted cancer immunotherapy Yu, Xiaofei Wang, Xiang-Yang Oncoimmunology Author's View Extensive studies have established a role of scavenger receptor CD204 in pattern recognition and ligand uptake. Strikingly, we recently revealed a previously unrecognized feature of CD204 action in attenuating T-cell activation and antitumor immunity. Blocking its activity in dendritic cells represents a promising approach to the improvement of cancer immunotherapy. Landes Bioscience 2012-08-01 /pmc/articles/PMC3429590/ /pubmed/22934278 http://dx.doi.org/10.4161/onci.19728 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Yu, Xiaofei
Wang, Xiang-Yang
Antagonizing the innate pattern recognition receptor CD204 to improve dendritic cell-targeted cancer immunotherapy
title Antagonizing the innate pattern recognition receptor CD204 to improve dendritic cell-targeted cancer immunotherapy
title_full Antagonizing the innate pattern recognition receptor CD204 to improve dendritic cell-targeted cancer immunotherapy
title_fullStr Antagonizing the innate pattern recognition receptor CD204 to improve dendritic cell-targeted cancer immunotherapy
title_full_unstemmed Antagonizing the innate pattern recognition receptor CD204 to improve dendritic cell-targeted cancer immunotherapy
title_short Antagonizing the innate pattern recognition receptor CD204 to improve dendritic cell-targeted cancer immunotherapy
title_sort antagonizing the innate pattern recognition receptor cd204 to improve dendritic cell-targeted cancer immunotherapy
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429590/
https://www.ncbi.nlm.nih.gov/pubmed/22934278
http://dx.doi.org/10.4161/onci.19728
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