Development of a novel universal immune receptor for antigen targeting: To Infinity and beyond

Chimeric antigen receptors (CARs) possess fixed specificity for a single antigen and require empirical testing in T cells. To address this, we have developed a novel, adaptable immune receptor strategy that allows for the rapid generation and testing of T cells of nearly infinite antigen specificity...

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Detalles Bibliográficos
Autores principales: Urbanska, Katarzyna, Powell, Daniel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429592/
https://www.ncbi.nlm.nih.gov/pubmed/22934280
http://dx.doi.org/10.4161/onci.19730
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author Urbanska, Katarzyna
Powell, Daniel J.
author_facet Urbanska, Katarzyna
Powell, Daniel J.
author_sort Urbanska, Katarzyna
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description Chimeric antigen receptors (CARs) possess fixed specificity for a single antigen and require empirical testing in T cells. To address this, we have developed a novel, adaptable immune receptor strategy that allows for the rapid generation and testing of T cells of nearly infinite antigen specificity.
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spelling pubmed-34295922012-08-29 Development of a novel universal immune receptor for antigen targeting: To Infinity and beyond Urbanska, Katarzyna Powell, Daniel J. Oncoimmunology Author's View Chimeric antigen receptors (CARs) possess fixed specificity for a single antigen and require empirical testing in T cells. To address this, we have developed a novel, adaptable immune receptor strategy that allows for the rapid generation and testing of T cells of nearly infinite antigen specificity. Landes Bioscience 2012-08-01 /pmc/articles/PMC3429592/ /pubmed/22934280 http://dx.doi.org/10.4161/onci.19730 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Urbanska, Katarzyna
Powell, Daniel J.
Development of a novel universal immune receptor for antigen targeting: To Infinity and beyond
title Development of a novel universal immune receptor for antigen targeting: To Infinity and beyond
title_full Development of a novel universal immune receptor for antigen targeting: To Infinity and beyond
title_fullStr Development of a novel universal immune receptor for antigen targeting: To Infinity and beyond
title_full_unstemmed Development of a novel universal immune receptor for antigen targeting: To Infinity and beyond
title_short Development of a novel universal immune receptor for antigen targeting: To Infinity and beyond
title_sort development of a novel universal immune receptor for antigen targeting: to infinity and beyond
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429592/
https://www.ncbi.nlm.nih.gov/pubmed/22934280
http://dx.doi.org/10.4161/onci.19730
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