Cross-platform pathway-based analysis identifies markers of response to the PARP inhibitor olaparib

Poly(ADP-ribose) polymerase (PARP) is an enzyme involved in DNA repair. PARP inhibitors can act as chemosensitizers, or operate on the principle of synthetic lethality when used as single agent. Clinical trials have shown drugs in this class to be promising for BRCA mutation carriers. We postulated...

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Detalles Bibliográficos
Autores principales: Daemen, Anneleen, Wolf, Denise M., Korkola, James E., Griffith, Obi L., Frankum, Jessica R., Brough, Rachel, Jakkula, Lakshmi R., Wang, Nicholas J., Natrajan, Rachael, Reis-Filho, Jorge S., Lord, Christopher J., Ashworth, Alan, Spellman, Paul T., Gray, Joe W., van’t Veer, Laura J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2012
Materias:
Preclinical Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429780/
https://www.ncbi.nlm.nih.gov/pubmed/22875744
http://dx.doi.org/10.1007/s10549-012-2188-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429780/
https://www.ncbi.nlm.nih.gov/pubmed/22875744
http://dx.doi.org/10.1007/s10549-012-2188-0

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