Crystal structure of the dopamine N-acetyltransferase–acetyl-CoA complex provides insights into the catalytic mechanism

The daily cycle of melatonin biosynthesis in mammals is regulated by AANAT (arylalkylamine N-acetyltransferase; EC 2.3.1.87), making it an attractive target for therapeutic control of abnormal melatonin production in mood and sleep disorders. Drosophila melanogaster Dat (dopamine N-acetyltransferase...

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Detalles Bibliográficos
Autores principales: Cheng, Kuo-Chang, Liao, Jhen-Ni, Lyu, Ping-Chiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429931/
https://www.ncbi.nlm.nih.gov/pubmed/22716280
http://dx.doi.org/10.1042/BJ20120520

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429931/
https://www.ncbi.nlm.nih.gov/pubmed/22716280
http://dx.doi.org/10.1042/BJ20120520

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