Cargando…

Crystal structure of the dopamine N-acetyltransferase–acetyl-CoA complex provides insights into the catalytic mechanism

The daily cycle of melatonin biosynthesis in mammals is regulated by AANAT (arylalkylamine N-acetyltransferase; EC 2.3.1.87), making it an attractive target for therapeutic control of abnormal melatonin production in mood and sleep disorders. Drosophila melanogaster Dat (dopamine N-acetyltransferase...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cheng, Kuo-Chang, Liao, Jhen-Ni, Lyu, Ping-Chiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429931/ https://www.ncbi.nlm.nih.gov/pubmed/22716280 http://dx.doi.org/10.1042/BJ20120520

Ejemplares similares

Crystal Structure of the N-Acetyltransferase Domain of Human N-Acetyl-L-Glutamate Synthase in Complex with N-Acetyl-L-Glutamate Provides Insights into Its Catalytic and Regulatory Mechanisms
por: Zhao, Gengxiang, et al.
Publicado: (2013)

An essential role of acetyl coenzyme A in the catalytic cycle of insect arylalkylamine N-acetyltransferase
por: Wu, Chu-Ya, et al.
Publicado: (2020)

Acetyl group coordinated progression through the catalytic cycle of an arylalkylamine N-acetyltransferase
por: Aboalroub, Adam A., et al.
Publicado: (2017)

Characterization of Acetyl-CoA: Lyso-PAF Acetyltransferase of Human Mesangial Cells
por: Fragopoulou, Elizabeth, et al.
Publicado: (2005)

Role of acetyl-CoA acetyltransferase 1 expression in the molecular mechanism of adenomyosis
por: Yalaza, Cem, et al.
Publicado: (2023)

Histone acetyltransferase NAA40 modulates acetyl-CoA levels and lipid synthesis
por: Charidemou, Evelina, et al.
Publicado: (2022)

Crystal structure of an acetyl esterase complexed with acetate ion provides insights into the catalytic mechanism
por: Uechi, Keiko, et al.
Publicado: (2016)

Integrated omics approach to unveil antifungal bacterial polyynes as acetyl-CoA acetyltransferase inhibitors
por: Lin, Ching-Chih, et al.
Publicado: (2022)

Epigenetic Inactivation of Acetyl-CoA Acetyltransferase 1 Promotes the Proliferation and Metastasis in Nasopharyngeal Carcinoma by Blocking Ketogenesis
por: Lu, Yunliang, et al.
Publicado: (2021)

Chemoproteomic Profiling of Lysine Acetyltransferases Highlights an Expanded Landscape of Catalytic Acetylation
por: Montgomery, David C., et al.
Publicado: (2014)

Structures of chloramphenicol acetyltransferase III and Escherichia coli β-ketoacylsynthase III co-crystallized with partially hydrolysed acetyl-oxa(dethia)CoA
por: Benjamin, Aaron B., et al.
Publicado: (2023)

Identification and cytochemical immunolocalization of acetyl-CoA acetyltransferase involved in the terpenoid mevalonate pathway in Euphorbia helioscopia laticifers
por: Wang, Meng, et al.
Publicado: (2017)

Cloning, characterization, and functional analysis of acetyl-CoA C-acetyltransferase and 3-hydroxy-3-methylglutaryl-CoA synthase genes in Santalum album
por: Niu, Meiyun, et al.
Publicado: (2021)

Sirtuin 5 regulates the proliferation, invasion and migration of prostate cancer cells through acetyl‐CoA acetyltransferase 1
por: Guan, Jingqian, et al.
Publicado: (2020)

Molecular Cloning and Analysis of an Acetyl-CoA C-acetyltransferase Gene (EkAACT) from Euphorbia kansui Liou
por: Wang, Meng, et al.
Publicado: (2022)

Lysine acetyltransferase NuA4 and acetyl-CoA regulate glucose-deprived stress granule formation in Saccharomyces cerevisiae
por: Rollins, Meaghen, et al.
Publicado: (2017)

Endoplasmic reticulum acetyltransferases Atase1 and Atase2 differentially regulate reticulophagy, macroautophagy and cellular acetyl-CoA metabolism
por: Rigby, Michael J., et al.
Publicado: (2021)

Dynamics-function relationship in the catalytic domains of N-terminal acetyltransferases
por: Abboud, Angèle, et al.
Publicado: (2020)

Improved genotyping of N-acetyltransferase 2: role of the ultra-slow acetylators
por: Blaszkewicz, Meinolf
Publicado: (2013)

Acetylator Genotype-Dependent Dyslipidemia in Rats Congenic for N-Acetyltransferase 2
por: Hong, Kyung U., et al.
Publicado: (2020)

Arylamine N-Acetyltransferase 1 Activity is Regulated by the Protein Acetylation Status
por: Salazar-González, Raúl A., et al.
Publicado: (2022)

Molecular Cloning, Characterization, and Functional Analysis of Acetyl-CoA C-Acetyltransferase and Mevalonate Kinase Genes Involved in Terpene Trilactone Biosynthesis from Ginkgo biloba
por: Chen, Qiangwen, et al.
Publicado: (2017)

An N-acetyltransferase required for ESAT-6 N-terminal acetylation and virulence in Mycobacterium marinum
por: Collars, Owen A., et al.
Publicado: (2023)

N-hydroxyarylamine O-acetyltransferase of Salmonella typhimurium: proposal for a common catalytic mechanism of arylamine acetyltransferase enzymes.
por: Watanabe, M, et al.
Publicado: (1994)

An Approach to Identify SNPs in the Gene Encoding Acetyl-CoA Acetyltransferase-2 (ACAT-2) and Their Proposed Role in Metabolic Processes in Pig
por: Sodhi, Simrinder Singh, et al.
Publicado: (2014)

Determinants within the C-Terminal Domain of Streptomyces lividans Acetyl-CoA Synthetase that Block Acetylation of Its Active Site Lysine In Vitro by the Protein Acetyltransferase (Pat) Enzyme
por: Tucker, Alex C., et al.
Publicado: (2014)

N-terminal Acetylation Levels Are Maintained During Acetyl-CoA Deficiency in Saccharomyces cerevisiae
por: Varland, Sylvia, et al.
Publicado: (2018)

Correlation of N-Acetyltransferase 2 Genotype with Isoniazid Acetylation in Polish Tuberculosis Patients
por: Zabost, Anna, et al.
Publicado: (2013)

Dual lysine and N‐terminal acetyltransferases reveal the complexity underpinning protein acetylation
por: Bienvenut, Willy V, et al.
Publicado: (2020)

Unexpected Acetylation of Endogenous Aliphatic Amines by Arylamine N‐Acetyltransferase NAT2
por: Conway, Louis P., et al.
Publicado: (2020)

From Arylamine N-Acetyltransferase to Folate-Dependent Acetyl CoA Hydrolase: Impact of Folic Acid on the Activity of (HUMAN)NAT1 and Its Homologue (MOUSE)NAT2
por: Laurieri, Nicola, et al.
Publicado: (2014)

Structural characterization of a GNAT family acetyltransferase from Elizabethkingia anophelis bound to acetyl-CoA reveals a new dimeric interface
por: Shirmast, P., et al.
Publicado: (2021)

Autophagy inhibition and reactive oxygen species elimination by acetyl-CoA acetyltransferase 1 through fused in sarcoma protein to promote prostate cancer
por: Guan, Jingqian, et al.
Publicado: (2022)

Arylamine N-acetyltransferase 2 genotype-dependent N-acetylation of isoniazid in cryopreserved human hepatocytes
por: Doll, Mark A., et al.
Publicado: (2017)

An N-acetyltransferase required for EsxA N-terminal protein acetylation and virulence in Mycobacterium marinum
por: Collars, Owen A., et al.
Publicado: (2023)

Acetyl-CoA Carboxylases and Diseases
por: Wang, Yu, et al.
Publicado: (2022)

ACETYL-COA SYNTHETASE REGULATES HISTONE ACETYLATION AND HIPPOCAMPAL MEMORY
por: Mews, Philipp, et al.
Publicado: (2017)

N-acetylaspartate catabolism determines cytosolic acetyl-CoA levels and histone acetylation in brown adipocytes
por: Prokesch, A., et al.
Publicado: (2016)

Novel insights into the role of acetyl-CoA producing enzymes in epigenetic regulation
por: Russo, Marta, et al.
Publicado: (2023)

The genome of the basal agaricomycete Xanthophyllomyces dendrorhous provides insights into the organization of its acetyl-CoA derived pathways and the evolution of Agaricomycotina
por: Sharma, Rahul, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_28sjp9mv5jnk5gnt8868vce3ic