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Local amplification of glucocorticoids in the aging brain and impaired spatial memory

The hippocampus is a prime target for glucocorticoids (GCs) and a brain structure particularly vulnerable to aging. Prolonged exposure to excess GCs compromises hippocampal electrophysiology, structure, and function. Blood GC levels tend to increase with aging and correlate with impaired spatial mem...

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Detalles Bibliográficos
Autores principales: Yau, Joyce L. W., Seckl, Jonathan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430012/
https://www.ncbi.nlm.nih.gov/pubmed/22952463
http://dx.doi.org/10.3389/fnagi.2012.00024