ATM and MET kinases are synthetic lethal with non-genotoxic activation of p53

The p53 tumor suppressor orchestrates alternative stress responses including cell cycle arrest and apoptosis, but the mechanisms defining cell fate upon p53 activation are poorly understood. Several small molecule activators of p53 have been developed, including Nutlin-3, but their therapeutic poten...

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Detalles Bibliográficos
Autores principales: Sullivan, Kelly D., Padilla-Just, Nuria, Henry, Ryan E., Porter, Christopher C., Kim, Jihye, Tentler, John J., Eckhardt, S. Gail, Tan, Aik Choon, DeGregori, James, Espinosa, Joaquín M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430605/
https://www.ncbi.nlm.nih.gov/pubmed/22660439
http://dx.doi.org/10.1038/nchembio.965

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430605/
https://www.ncbi.nlm.nih.gov/pubmed/22660439
http://dx.doi.org/10.1038/nchembio.965

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