Granzyme B-Induced Neurotoxicity Is Mediated via Activation of PAR-1 Receptor and Kv1.3 Channel

Increasing evidence supports a critical role of T cells in neurodegeneration associated with acute and subacute brain inflammatory disorders. Granzyme B (GrB), released by activated T cells, is a cytotoxic proteinase which may induce perforin-independent neurotoxicity. Here, we studied the mechanism...

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Detalles Bibliográficos
Autores principales: Wang, Tongguang, Lee, Myoung-Hwa, Choi, Elliot, Pardo-Villamizar, Carlos A., Lee, Sung Bin, Yang, In Hong, Calabresi, Peter A., Nath, Avindra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430617/
https://www.ncbi.nlm.nih.gov/pubmed/22952817
http://dx.doi.org/10.1371/journal.pone.0043950

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430617/
https://www.ncbi.nlm.nih.gov/pubmed/22952817
http://dx.doi.org/10.1371/journal.pone.0043950

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