Cargando…

Granzyme B-Induced Neurotoxicity Is Mediated via Activation of PAR-1 Receptor and Kv1.3 Channel

Increasing evidence supports a critical role of T cells in neurodegeneration associated with acute and subacute brain inflammatory disorders. Granzyme B (GrB), released by activated T cells, is a cytotoxic proteinase which may induce perforin-independent neurotoxicity. Here, we studied the mechanism...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Tongguang, Lee, Myoung-Hwa, Choi, Elliot, Pardo-Villamizar, Carlos A., Lee, Sung Bin, Yang, In Hong, Calabresi, Peter A., Nath, Avindra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430617/ https://www.ncbi.nlm.nih.gov/pubmed/22952817 http://dx.doi.org/10.1371/journal.pone.0043950

Ejemplares similares

Blockade of Kv1.3 Potassium Channels Inhibits Differentiation and Granzyme B Secretion of Human CD8+ T Effector Memory Lymphocytes
por: Hu, Lina, et al.
Publicado: (2013)

Protease-activated receptor-1 activation by granzyme B causes neurotoxicity that is augmented by interleukin-1β
por: Lee, Paul R., et al.
Publicado: (2017)

The Mitochondrial Routing of the Kv1.3 Channel
por: Capera, Jesusa, et al.
Publicado: (2022)

The voltage-dependent K(+) channels Kv1.3 and Kv1.5 in human cancer
por: Comes, Núria, et al.
Publicado: (2013)

Modulation of the Kv1.3 Potassium Channel by Receptor Tyrosine Kinases
por: Bowlby, Mark R., et al.
Publicado: (1997)

Scorpion toxins targeting Kv1.3 channels: insights into immunosuppression
por: Oliveira, Isadora S, et al.
Publicado: (2019)

Assembly and suppression of endogenous Kv1.3 channels in human T cells
Publicado: (1996)

Mitochondrial Kv1.3 Channels as Target for Treatment of Multiple Myeloma
por: Kadow, Stephanie, et al.
Publicado: (2022)

Structures of the T cell potassium channel Kv1.3 with immunoglobulin modulators
por: Selvakumar, Purushotham, et al.
Publicado: (2022)

Inhibition of the potassium channel Kv1.3 reduces infarction and inflammation in ischemic stroke
por: Chen, Yi‐Je, et al.
Publicado: (2017)

HIV-Tat protein and amyloid β peptide form multifibrillar structures that cause neurotoxicity
por: Hategan, Alina, et al.
Publicado: (2017)

Mechanisms Underlying C-type Inactivation in Kv Channels: Lessons From Structures of Human Kv1.3 and Fly Shaker-IR Channels
por: Ong, Seow Theng, et al.
Publicado: (2022)

Effect of Methamphetamine on the Microglial Damage: Role of Potassium Channel Kv1.3
por: Wang, Jun, et al.
Publicado: (2014)

Inhibition of Kv1.3 Channels in Human Jurkat T Cells by Xanthohumol and Isoxanthohumol
por: Gąsiorowska, Justyna, et al.
Publicado: (2015)

Expression and function of Kv1.3 channel in malignant T cells in Sézary syndrome
por: Hu, Tengpeng, et al.
Publicado: (2019)

Mapping the Interaction Anatomy of BmP02 on Kv1.3 Channel
por: Wu, B., et al.
Publicado: (2016)

Pharmacological blockade of KV1.3 channel as a promising treatment in autoimmune diseases
por: Cañas, Carlos A., et al.
Publicado: (2022)

Mitochondrial Ultrastructure and Glucose Signaling Pathways Attributed to the Kv1.3 Ion Channel
por: Kovach, Christopher P., et al.
Publicado: (2016)

Fluconazole Is Neuroprotective via Interactions with the IGF-1 Receptor
por: Toodle, Valerie, et al.
Publicado: (2022)

Potassium Channels Kv1.3 and Kir2.1 But Not Kv1.5 Contribute to BV2 Cell Line and Primary Microglial Migration
por: Anton, Ruxandra, et al.
Publicado: (2021)

Open channel block of Kv1.4 potassium channels by aripiprazole
por: Park, Jeaneun, et al.
Publicado: (2020)

Computational Insights of the Interaction among Sea Anemones Neurotoxins and Kv1.3 Channel
por: Sabogal-Arango, Angélica, et al.
Publicado: (2014)

Voltage-Gated Potassium Channel Kv1.3 as a Target in Therapy of Cancer
por: Teisseyre, Andrzej, et al.
Publicado: (2019)

Statins as inhibitors of voltage-gated potassium channels Kv1.3 in cancer cells
por: Teisseyre, Andrzej, et al.
Publicado: (2021)

The potassium channel Kv1.3 as a therapeutic target for immunocytoprotection after reperfusion
por: Chen, Yi‐Je, et al.
Publicado: (2021)

Blockade of Kv1.3 Potassium Channel Inhibits Microglia-Mediated Neuroinflammation in Epilepsy
por: Zhang, Xinyi, et al.
Publicado: (2022)

The Phosphorylation of Kv1.3: A Modulatory Mechanism for a Multifunctional Ion Channel
por: Navarro-Pérez, María, et al.
Publicado: (2023)

Mechanism of functional interaction between potassium channel Kv1.3 and sodium channel NavBeta1 subunit
por: Kubota, Tomoya, et al.
Publicado: (2017)

Inhibition of Kv10.1 Channels Sensitizes Mitochondria of Cancer Cells to Antimetabolic Agents
por: Hernández-Reséndiz, Ileana, et al.
Publicado: (2020)

Kv1.3 Channel Blockade Modulates the Effector Function of B Cells in Granulomatosis with Polyangiitis
por: Land, Judith, et al.
Publicado: (2017)

Regulation of K(+) Conductance by a Hydrogen Bond in Kv2.1, Kv2.2, and Kv1.2 Channels
por: Zhang, Yuchen, et al.
Publicado: (2021)

Guiding TRAIL to cancer cells through Kv10.1 potassium channel overcomes resistance to doxorubicin
por: Hartung, Franziska, et al.
Publicado: (2016)

Roles of Lymphocyte Kv1.3-Channels in the Pathogenesis of Renal Diseases and Novel Therapeutic Implications of Targeting the Channels
por: Kazama, Itsuro
Publicado: (2015)

Blockade of Kv1.5 channels by the antidepressant drug sertraline
por: Lee, Hyang Mi, et al.
Publicado: (2016)

Kv7 and Kv11 channels in myometrial regulation
por: Greenwood, Iain A, et al.
Publicado: (2014)

Dynamics of Kv1 Channel Transport in Axons
por: Gu, Yuanzheng, et al.
Publicado: (2010)

Kv1 channel inactivation: Slow and slower
por: Short, Ben
Publicado: (2022)

Clofazimine Inhibits Human Kv1.3 Potassium Channel by Perturbing Calcium Oscillation in T Lymphocytes
por: Ren, Yunzhao R., et al.
Publicado: (2008)

Physiological Role of Kv1.3 Channel in T Lymphocyte Cell Investigated Quantitatively by Kinetic Modeling
por: Hou, Panpan, et al.
Publicado: (2014)

Eplerenone Reverses Cardiac Fibrosis via the Suppression of Tregs by Inhibition of Kv1.3 Channel
por: Shao, Pei-Pei, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_94l244i5kkke3866bjb9iscdeq