ATXN2-CAG42 Sequesters PABPC1 into Insolubility and Induces FBXW8 in Cerebellum of Old Ataxic Knock-In Mice

Spinocerebellar Ataxia Type 2 (SCA2) is caused by expansion of a polyglutamine encoding triplet repeat in the human ATXN2 gene beyond (CAG)(31). This is thought to mediate toxic gain-of-function by protein aggregation and to affect RNA processing, resulting in degenerative processes affecting prefer...

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Detalles Bibliográficos
Autores principales: Damrath, Ewa, Heck, Melanie V., Gispert, Suzana, Azizov, Mekhman, Nowock, Joachim, Seifried, Carola, Rüb, Udo, Walter, Michael, Auburger, Georg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431311/
https://www.ncbi.nlm.nih.gov/pubmed/22956915
http://dx.doi.org/10.1371/journal.pgen.1002920

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431311/
https://www.ncbi.nlm.nih.gov/pubmed/22956915
http://dx.doi.org/10.1371/journal.pgen.1002920

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