Cargando…

The PARN Deadenylase Targets a Discrete Set of mRNAs for Decay and Regulates Cell Motility in Mouse Myoblasts

PARN is one of several deadenylase enzymes present in mammalian cells, and as such the contribution it makes to the regulation of gene expression is unclear. To address this, we performed global mRNA expression and half-life analysis on mouse myoblasts depleted of PARN. PARN knockdown resulted in th...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Jerome E., Lee, Ju Youn, Trembly, Jarrett, Wilusz, Jeffrey, Tian, Bin, Wilusz, Carol J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431312/
https://www.ncbi.nlm.nih.gov/pubmed/22956911
http://dx.doi.org/10.1371/journal.pgen.1002901