Combining Comparative Proteomics and Molecular Genetics Uncovers Regulators of Synaptic and Axonal Stability and Degeneration In Vivo

Degeneration of synaptic and axonal compartments of neurons is an early event contributing to the pathogenesis of many neurodegenerative diseases, but the underlying molecular mechanisms remain unclear. Here, we demonstrate the effectiveness of a novel “top-down” approach for identifying proteins an...

Descripción completa

Detalles Bibliográficos
Autores principales: Wishart, Thomas M., Rooney, Timothy M., Lamont, Douglas J., Wright, Ann K., Morton, A. Jennifer, Jackson, Mandy, Freeman, Marc R., Gillingwater, Thomas H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431337/
https://www.ncbi.nlm.nih.gov/pubmed/22952455
http://dx.doi.org/10.1371/journal.pgen.1002936

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431337/
https://www.ncbi.nlm.nih.gov/pubmed/22952455
http://dx.doi.org/10.1371/journal.pgen.1002936

Ejemplares similares