Cargando…

Combining Comparative Proteomics and Molecular Genetics Uncovers Regulators of Synaptic and Axonal Stability and Degeneration In Vivo

Degeneration of synaptic and axonal compartments of neurons is an early event contributing to the pathogenesis of many neurodegenerative diseases, but the underlying molecular mechanisms remain unclear. Here, we demonstrate the effectiveness of a novel “top-down” approach for identifying proteins an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wishart, Thomas M., Rooney, Timothy M., Lamont, Douglas J., Wright, Ann K., Morton, A. Jennifer, Jackson, Mandy, Freeman, Marc R., Gillingwater, Thomas H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431337/ https://www.ncbi.nlm.nih.gov/pubmed/22952455 http://dx.doi.org/10.1371/journal.pgen.1002936

Ejemplares similares

Temporal Profiling of the Cortical Synaptic Mitochondrial Proteome Identifies Ageing Associated Regulators of Stability
por: Graham, Laura C., et al.
Publicado: (2021)

Proteomic mapping of differentially vulnerable pre-synaptic populations identifies regulators of neuronal stability in vivo
por: Llavero Hurtado, Maica, et al.
Publicado: (2017)

Proteomic profiling of neuronal mitochondria reveals modulators of synaptic architecture
por: Graham, Laura C., et al.
Publicado: (2017)

Molecular analysis of axonal-intrinsic and glial-associated co-regulation of axon degeneration
por: Catenaccio, Alejandra, et al.
Publicado: (2017)

Synaptic Protection in the Brain of Wld(S) Mice Occurs Independently of Age but Is Sensitive to Gene-Dose
por: Wright, Ann K., et al.
Publicado: (2010)

Label-free proteomics identifies Calreticulin and GRP75/Mortalin as peripherally accessible protein biomarkers for spinal muscular atrophy
por: Mutsaers, Chantal A, et al.
Publicado: (2013)

Molecular correlates of axonal and synaptic pathology in mouse models of Batten disease
por: Kielar, Catherine, et al.
Publicado: (2009)

Sideroflexin 3 is an α-synuclein-dependent mitochondrial protein that regulates synaptic morphology
por: Amorim, Inês S., et al.
Publicado: (2017)

Uncovering Discrete Synaptic Proteomes to Understand Neurological Disorders
por: Wang, Yi-Zhi, et al.
Publicado: (2018)

Molecular Mechanisms Underlying Synaptic and Axon Degeneration in Parkinson’s Disease
por: Gcwensa, Nolwazi Z., et al.
Publicado: (2021)

Are neuropsychiatric symptoms in dementia linked to CSF biomarkers of synaptic and axonal degeneration?
por: Bloniecki, Victor, et al.
Publicado: (2020)

Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype
por: Hesse, Raphael, et al.
Publicado: (2019)

Cerebrospinal fluid biomarkers of axonal and synaptic degeneration in a population-based sample
por: Arvidsson Rådestig, Maya, et al.
Publicado: (2023)

Modified cell cycle status in a mouse model of altered neuronal vulnerability (slow Wallerian degeneration; Wld(s))
por: Wishart, Thomas M, et al.
Publicado: (2008)

Expression of the neuroprotective slow Wallerian degeneration (Wld(S)) gene in non-neuronal tissues
por: Wishart, Thomas M, et al.
Publicado: (2009)

Synaptic proteomics reveal distinct molecular signatures of cognitive change and C9ORF72 repeat expansion in the human ALS cortex
por: Laszlo, Zsofia I., et al.
Publicado: (2022)

The ubiquitin proteasome system in synaptic and axonal degeneration: a new twist to an old cycle
por: Korhonen, Laura, et al.
Publicado: (2004)

FAIM-L regulation of XIAP degradation modulates Synaptic Long-Term Depression and Axon Degeneration
por: Martínez-Mármol, Ramón, et al.
Publicado: (2016)

Axon degeneration: Linking axonal bioenergetics to myelin
por: Beirowski, Bogdan, et al.
Publicado: (2016)

An Optimized Comparative Proteomic Approach as a Tool in Neurodegenerative Disease Research
por: Kline, Rachel A., et al.
Publicado: (2022)

Design of a novel quantitative PCR (QPCR)-based protocol for genotyping mice carrying the neuroprotective Wallerian degeneration slow (Wld(s)) gene
por: Wishart, Thomas M, et al.
Publicado: (2007)

Approaches to quantify axonal morphology for the analysis of axonal degeneration
por: Palumbo, Alex, et al.
Publicado: (2022)

Multifaceted roles of SARM1 in axon degeneration and signaling
por: Waller, Thomas J., et al.
Publicado: (2022)

At the centre of neuronal, synaptic and axonal pathology in murine prion disease: degeneration of neuroanatomically linked thalamic and brainstem nuclei
por: Reis, Renata, et al.
Publicado: (2015)

Loss of the extracellular matrix protein Perlecan disrupts axonal and synaptic stability during Drosophila development
por: Guss, Ellen J, et al.
Publicado: (2023)

Axon Biology in ALS: Mechanisms of Axon Degeneration and Prospects for Therapy
por: Coleman, Michael P.
Publicado: (2022)

Longitudinal in vivo monitoring of axonal degeneration after brain injury
por: Chornyy, Sergiy, et al.
Publicado: (2023)

Uncovering multiple axonal targeting pathways in hippocampal neurons
por: Wisco, Dolora, et al.
Publicado: (2003)

Chronic oxycodone induces axonal degeneration in rat brain
por: Fan, Ruping, et al.
Publicado: (2018)

Uncovering the link between synaptic density and mental illness through in vivo imaging
por: Smart, Kelly, et al.
Publicado: (2023)

HIV-associated synaptic degeneration
por: Ru, Wenjuan, et al.
Publicado: (2017)

SYNAPTIC POTENTIAL IN THE MOTOR GIANT AXON OF THE CRAYFISH
por: Hagiwara, Susumu
Publicado: (1958)

Axonal filopodial asymmetry induced by synaptic target
por: Li, Pan P., et al.
Publicado: (2011)

Axonal Noise as a Source of Synaptic Variability
por: Neishabouri, Ali, et al.
Publicado: (2014)

Retrograde Axonal Degeneration in Parkinson Disease
por: Tagliaferro, Patricia, et al.
Publicado: (2016)

Mitochondrial Behavior in Axon Degeneration and Regeneration
por: Wang, Biyao, et al.
Publicado: (2021)

In vivo imaging of injured cortical axons reveals a rapid onset form of Wallerian degeneration
por: Canty, Alison Jane, et al.
Publicado: (2020)

Imaging Axonal Degeneration and Repair in Preclinical Animal Models of Multiple Sclerosis
por: Yandamuri, Soumya S., et al.
Publicado: (2016)

Comparative proteomic profiling reveals mechanisms for early spinal cord vulnerability in CLN1 disease
por: Nelvagal, Hemanth R., et al.
Publicado: (2020)

Regional Molecular Mapping of Primate Synapses during Normal Healthy Aging
por: Graham, Laura C., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_s6l2h426vish1nbgbi5upr3cb4