Ablation of the Regulatory IE1 Protein of Murine Cytomegalovirus Alters In Vivo Pro-inflammatory TNF-alpha Production during Acute Infection

Little is known about the role of viral genes in modulating host cytokine responses. Here we report a new functional role of the viral encoded IE1 protein of the murine cytomegalovirus in sculpting the inflammatory response in an acute infection. In time course experiments of infected primary macrop...

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Detalles Bibliográficos
Autores principales: Rodríguez-Martín, Sara, Kropp, Kai Alexander, Wilhelmi, Vanessa, Lisnic, Vanda Juranic, Hsieh, Wei Yuan, Blanc, Mathieu, Livingston, Andrew, Busche, Andreas, Tekotte, Hille, Messerle, Martin, Auer, Manfred, Fraser, Iain, Jonjic, Stipan, Angulo, Ana, Reddehase, Matthias J., Ghazal, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431344/
https://www.ncbi.nlm.nih.gov/pubmed/22952450
http://dx.doi.org/10.1371/journal.ppat.1002901

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431344/
https://www.ncbi.nlm.nih.gov/pubmed/22952450
http://dx.doi.org/10.1371/journal.ppat.1002901

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