Cargando…

Ablation of the Regulatory IE1 Protein of Murine Cytomegalovirus Alters In Vivo Pro-inflammatory TNF-alpha Production during Acute Infection

Little is known about the role of viral genes in modulating host cytokine responses. Here we report a new functional role of the viral encoded IE1 protein of the murine cytomegalovirus in sculpting the inflammatory response in an acute infection. In time course experiments of infected primary macrop...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rodríguez-Martín, Sara, Kropp, Kai Alexander, Wilhelmi, Vanessa, Lisnic, Vanda Juranic, Hsieh, Wei Yuan, Blanc, Mathieu, Livingston, Andrew, Busche, Andreas, Tekotte, Hille, Messerle, Martin, Auer, Manfred, Fraser, Iain, Jonjic, Stipan, Angulo, Ana, Reddehase, Matthias J., Ghazal, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431344/ https://www.ncbi.nlm.nih.gov/pubmed/22952450 http://dx.doi.org/10.1371/journal.ppat.1002901

Ejemplares similares

Dual Analysis of the Murine Cytomegalovirus and Host Cell Transcriptomes Reveal New Aspects of the Virus-Host Cell Interface
por: Juranic Lisnic, Vanda, et al.
Publicado: (2013)

Murine CMV Expressing the High Affinity NKG2D Ligand MULT-1: A Model for the Development of Cytomegalovirus-Based Vaccines
por: Hiršl, Lea, et al.
Publicado: (2018)

Inflammatory monocytes and NK cells play a crucial role in DNAM-1–dependent control of cytomegalovirus infection
por: Lenac Rovis, Tihana, et al.
Publicado: (2016)

The murine cytomegalovirus M35 protein antagonizes type I IFN induction downstream of pattern recognition receptors by targeting NF-κB mediated transcription
por: Chan, Baca, et al.
Publicado: (2017)

Cytomegalovirus protein m154 perturbs the adaptor protein-1 compartment mediating broad-spectrum immune evasion
por: Strazic Geljic, Ivana, et al.
Publicado: (2020)

Memory CD8 T Cells Generated by Cytomegalovirus Vaccine Vector Expressing NKG2D Ligand Have Effector-Like Phenotype and Distinct Functional Features
por: Šustić, Marko, et al.
Publicado: (2021)

Decoding murine cytomegalovirus
por: Lodha, Manivel, et al.
Publicado: (2023)

Perinatal murine cytomegalovirus infection reshapes the transcriptional profile and functionality of NK cells
por: Rožmanić, Carmen, et al.
Publicado: (2023)

The Immunoevasive Function Encoded by the Mouse Cytomegalovirus Gene m152 Protects the Virus against T Cell Control in Vivo
por: Krmpotic, Astrid, et al.
Publicado: (1999)

Cytomegalovirus restricts ICOSL expression on antigen-presenting cells disabling T cell co-stimulation and contributing to immune evasion
por: Angulo, Guillem, et al.
Publicado: (2021)

The Cytomegalovirus Tegument Protein UL35 Antagonizes Pattern Recognition Receptor-Mediated Type I IFN Transcription
por: Fabits, Markus, et al.
Publicado: (2020)

Cytomegalovirus m154 Hinders CD48 Cell-Surface Expression and Promotes Viral Escape from Host Natural Killer Cell Control
por: Zarama, Angela, et al.
Publicado: (2014)

ST2 deletion enhances innate and acquired immunity to murine mammary carcinoma
por: Jovanovic, Ivan, et al.
Publicado: (2011)

A Unique Role of the Human Cytomegalovirus Small Capsid Protein in Capsid Assembly
por: Borst, Eva Maria, et al.
Publicado: (2022)

The Virus-Induced Upregulation of the miR-183/96/182 Cluster and the FoxO Family Protein Members Are Not Required for Efficient Replication of HSV-1
por: Zubković, Andreja, et al.
Publicado: (2022)

NK/ILC1 cells mediate neuroinflammation and brain pathology following congenital CMV infection
por: Kveštak, Daria, et al.
Publicado: (2021)

Endosomal Phosphatidylinositol-3-Phosphate-Associated Functions Are Dispensable for Establishment of the Cytomegalovirus Pre-Assembly Compartment but Essential for the Virus Growth
por: Marcelić, Marina, et al.
Publicado: (2021)

Cytomegaloviruses Exploit Recycling Rab Proteins in the Sequential Establishment of the Assembly Compartment
por: Lučin, Pero, et al.
Publicado: (2018)

Cytomegalovirus Infection and Inflammation in Developing Brain
por: Krstanović, Fran, et al.
Publicado: (2021)

The complex of MCMV proteins and MHC class I evades NK cell control and drives the evolution of virus-specific activating Ly49 receptors
por: Železnjak, Jelena, et al.
Publicado: (2019)

Manipulation of NKG2D Ligands by Cytomegaloviruses: Impact on Innate and Adaptive Immune Response
por: Slavuljica, Irena, et al.
Publicado: (2011)

Activation of Innate and Adaptive Immunity by a Recombinant Human Cytomegalovirus Strain Expressing an NKG2D Ligand
por: Tomić, Adriana, et al.
Publicado: (2016)

Production- and Purification-Relevant Properties of Human and Murine Cytomegalovirus
por: Ravlić, Sanda, et al.
Publicado: (2021)

CD8 T Cell Vaccines and a Cytomegalovirus-Based Vector Approach
por: Šustić, Marko, et al.
Publicado: (2021)

Non-redundant and Redundant Roles of Cytomegalovirus gH/gL Complexes in Host Organ Entry and Intra-tissue Spread
por: Lemmermann, Niels A. W., et al.
Publicado: (2015)

IL-33/ST2 pathway drives regulatory T cell dependent suppression of liver damage upon cytomegalovirus infection
por: Popovic, Branka, et al.
Publicado: (2017)

The Mouse Cytomegalovirus Gene m42 Targets Surface Expression of the Protein Tyrosine Phosphatase CD45 in Infected Macrophages
por: Thiel, Nadine, et al.
Publicado: (2016)

Human Cytomegalovirus Nuclear Capsids Associate with the Core Nuclear Egress Complex and the Viral Protein Kinase pUL97
por: Milbradt, Jens, et al.
Publicado: (2018)

Murine Models of Central Nervous System Disease following Congenital Human Cytomegalovirus Infections
por: Moulden, Jerome, et al.
Publicado: (2021)

NK cell activation through the NKG2D ligand MULT-1 is selectively prevented by the glycoprotein encoded by mouse cytomegalovirus gene m145
por: Krmpotic, Astrid, et al.
Publicado: (2005)

Intrinsic Contribution of Perforin to NK-Cell Homeostasis during Mouse Cytomegalovirus Infection
por: Arapović, Maja, et al.
Publicado: (2016)

Hierarchical and Redundant Lymphocyte Subset Control Precludes Cytomegalovirus Replication during Latent Infection
por: Polić, Bojan, et al.
Publicado: (1998)

Cross-Species Analysis of Innate Immune Antagonism by Cytomegalovirus IE1 Protein
por: Rothemund, Franziska, et al.
Publicado: (2022)

Reverse Genetics Modification of Cytomegalovirus Antigenicity and Immunogenicity by CD8 T-Cell Epitope Deletion and Insertion
por: Lemmermann, Niels A. W., et al.
Publicado: (2011)

Lack of XBP-1 Impedes Murine Cytomegalovirus Gene Expression
por: Drori, Adi, et al.
Publicado: (2014)

Analysis of Human Cytomegalovirus-Encoded SUMO Targets and Temporal Regulation of SUMOylation of the Immediate-Early Proteins IE1 and IE2 during Infection
por: Kim, Eui Tae, et al.
Publicado: (2014)

SARS-CoV-2 Spike and Nucleocapsid Antibody Response in Vaccinated Croatian Healthcare Workers and Infected Hospitalized Patients: A Single Center Cohort Study
por: Brlić, Paola Kučan, et al.
Publicado: (2022)

Adverse immunological imprinting by cytomegalovirus sensitizing for allergic airway disease
por: Reddehase, Matthias J.
Publicado: (2019)

Distinct MHC class I–dependent NK cell–activating receptors control cytomegalovirus infection in different mouse strains
por: Pyzik, Michał, et al.
Publicado: (2011)

Identification of compounds with anti-human cytomegalovirus activity that inhibit production of IE2 proteins
por: Beelontally, Rooksarr, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_d6ud5aplbbu0r116sqk4kf9502