Cortactin Is a Substrate of Activated Cdc42-Associated Kinase 1 (ACK1) during Ligand-induced Epidermal Growth Factor Receptor Downregulation

BACKGROUND: Epidermal growth factor receptor (EGFR) internalization following ligand binding controls EGFR downstream pathway signaling activity. Internalized EGFR is poly-ubiquitinated by Cbl to promote lysosome-mediated degradation and signal downregulation. ACK1 is a non-receptor tyrosine kinase...

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Detalles Bibliográficos
Autores principales: Kelley, Laura C., Weed, Scott A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431376/
https://www.ncbi.nlm.nih.gov/pubmed/22952966
http://dx.doi.org/10.1371/journal.pone.0044363

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431376/
https://www.ncbi.nlm.nih.gov/pubmed/22952966
http://dx.doi.org/10.1371/journal.pone.0044363

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