Cargando…

Cortactin Is a Substrate of Activated Cdc42-Associated Kinase 1 (ACK1) during Ligand-induced Epidermal Growth Factor Receptor Downregulation

BACKGROUND: Epidermal growth factor receptor (EGFR) internalization following ligand binding controls EGFR downstream pathway signaling activity. Internalized EGFR is poly-ubiquitinated by Cbl to promote lysosome-mediated degradation and signal downregulation. ACK1 is a non-receptor tyrosine kinase...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kelley, Laura C., Weed, Scott A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431376/ https://www.ncbi.nlm.nih.gov/pubmed/22952966 http://dx.doi.org/10.1371/journal.pone.0044363

Ejemplares similares

The brain-specific splice variant of the CDC42 GTPase works together with the kinase ACK to downregulate the EGF receptor in promoting neurogenesis
por: Endo, Makoto, et al.
Publicado: (2022)

ACKnowledging the role of the Activated-Cdc42 associated kinase (ACK) in regulating protein stability in cancer
por: Hodder, Samantha, et al.
Publicado: (2023)

Assembly of nuclear dimers of PI3K regulatory subunits is regulated by the Cdc42-activated tyrosine kinase ACK
por: Clayton, Natasha S., et al.
Publicado: (2022)

Actin organization and endocytic trafficking are controlled by a network linking NIMA-related kinases to the CDC-42-SID-3/ACK1 pathway
por: Lažetić, Vladimir, et al.
Publicado: (2018)

Constitutive activated Cdc42-associated kinase (Ack) phosphorylation at arrested endocytic clathrin-coated pits of cells that lack dynamin
por: Shen, Hongying, et al.
Publicado: (2011)

Activated Cdc42-associated kinase 1 (ACK1) binds the sterile α motif (SAM) domain of the adaptor SLP-76 and phosphorylates proximal tyrosines
por: Thaker, Youg R., et al.
Publicado: (2017)

A dock and coalesce mechanism driven by hydrophobic interactions governs Cdc42 binding with its effector protein ACK
por: Tetley, George J. N., et al.
Publicado: (2017)

Domain Architecture of the Nonreceptor Tyrosine Kinase Ack1
por: Kan, Yagmur, et al.
Publicado: (2023)

Phosphorylation of Ack1 by the Receptor Tyrosine Kinase Mer
por: Hayashi, Samantha Y., et al.
Publicado: (2023)

Cortactin Phosphorylated by ERK1/2 Localizes to Sites of Dynamic Actin Regulation and Is Required for Carcinoma Lamellipodia Persistence
por: Kelley, Laura C., et al.
Publicado: (2010)

Regulation of Ack-Family Nonreceptor Tyrosine Kinases
por: Prieto-Echagüe, Victoria, et al.
Publicado: (2011)

Ack1: Activation and Regulation by Allostery
por: Gajiwala, Ketan S., et al.
Publicado: (2013)

Identification of novel Ack1-interacting proteins and Ack1 phosphorylated sites in mouse brain by mass spectrometry
por: del Mar Masdeu, Maria, et al.
Publicado: (2017)

Involvement of Activated Cdc42 Kinase1 in Colitis and Colorectal Neoplasms
por: Lv, Chaolan, et al.
Publicado: (2016)

The Borg family of Cdc42 effector proteins Cdc42EP1–5
por: Farrugia, Aaron J., et al.
Publicado: (2016)

Cortactin overexpression results in sustained epidermal growth factor receptor signaling by preventing ligand-induced receptor degradation in human carcinoma cells
por: van Rossum, Agnes GSH, et al.
Publicado: (2005)

A role for the tyrosine kinase ACK1 in neurotrophin signaling and neuronal extension and branching
por: La Torre, A, et al.
Publicado: (2013)

ACK1/TNK2 Tyrosine Kinase: Molecular Signaling and Evolving Role in Cancers
por: Mahajan, Kiran, et al.
Publicado: (2014)

Association of Cortactin, Fascin-1 and Epidermal Growth Factor Receptor (EGFR) Expression in Ovarian Carcinomas: Correlation with Clinicopathological Parameters
por: Lin, Chih-kung, et al.
Publicado: (2008)

Tyrosine dephosphorylated cortactin downregulates contractility at the epithelial zonula adherens through SRGAP1
por: Liang, Xuan, et al.
Publicado: (2017)

Cortactin is necessary for E-cadherin–mediated contact formation and actin reorganization
por: Helwani, Falak M., et al.
Publicado: (2004)

Dasatinib inhibits site-specific tyrosine phosphorylation of androgen receptor by Ack1 and Src kinases
por: Liu, Yuanbo, et al.
Publicado: (2010)

Interaction between androgen receptor and coregulator SLIRP is regulated by Ack1 tyrosine kinase and androgen
por: De Silva, Dinuka, et al.
Publicado: (2019)

The Impact of ackA, pta, and ackA-pta Mutations on Growth, Gene Expression and Protein Acetylation in Escherichia coli K-12
por: Schütze, Andrea, et al.
Publicado: (2020)

Regulation of Cdc42 for polarized growth in budding yeast
por: Miller, Kristi E., et al.
Publicado: (2020)

Research Progress of the Functional Role of ACK1 in Breast Cancer
por: Liu, Xia, et al.
Publicado: (2019)

Author Correction: Tyrosine dephosphorylated cortactin downregulates contractility at the epithelial zonula adherens through SRGAP1
por: Liang, Xuan, et al.
Publicado: (2017)

Hepatocyte Growth Factor-Dependent Antiviral Activity of Activated cdc42-Associated Kinase 1 Against Hepatitis B Virus
por: Lee, Hye Won, et al.
Publicado: (2021)

Cdc42 regulates Cdc42EP3 function in cancer-associated fibroblasts
por: Farrugia, Aaron J., et al.
Publicado: (2016)

Drosophila Activated Cdc42 Kinase Has an Anti-Apoptotic Function
por: Schoenherr, Jessica A., et al.
Publicado: (2012)

Regulation of polarized growth initiation and termination cycles by the polarisome and Cdc42 regulators
por: Bidlingmaier, Scott, et al.
Publicado: (2004)

Structural and mechanistic investigations on Salmonella typhimurium acetate kinase (AckA): identification of a putative ligand binding pocket at the dimeric interface
por: Chittori, Sagar, et al.
Publicado: (2012)

Cortactin and Crk cooperate to trigger actin polymerization during Shigella invasion of epithelial cells
por: Bougnères, Laurence, et al.
Publicado: (2004)

Androgen Receptor Activation in Castration-Recurrent Prostate Cancer: The Role of Src-Family and Ack1 Tyrosine Kinases
por: Gelman, Irwin H.
Publicado: (2014)

Cdc42 turns the spindle
por: Leslie, Mitch
Publicado: (2008)

The first buds of Cdc42
por: Short, Ben
Publicado: (2015)

Polo-like kinase 1 promotes Cdc42-induced actin polymerization for asymmetric division in oocytes
por: Yuen, Wai Shan, et al.
Publicado: (2023)

Cdc42 Effector Protein 3 Interacts With Cdc42 in Regulating Xenopus Somite Segmentation
por: Kho, Mary, et al.
Publicado: (2019)

Regulation of Ack1 localization and activity by the amino-terminal SAM domain
por: Prieto-Echagüe, Victoria, et al.
Publicado: (2010)

Prognostic significance of cortactin levels in head and neck squamous cell carcinoma: comparison with epidermal growth factor receptor status
por: Hofman, P, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_edk1kq7joj202sevv2vl6aouud