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The Minimal Deneddylase Core of the COP9 Signalosome Excludes the Csn6 MPN(−) Domain
The COP9 signalosome (CSN) is a eukaryotic protein complex, which regulates a wide range of biological processes mainly through modulating the cullin ubiquitin E3 ligases in the ubiquitin-proteasome pathway. The CSN possesses a highly conserved deneddylase activity that centers at the JAMM motif of...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431379/ https://www.ncbi.nlm.nih.gov/pubmed/22956996 http://dx.doi.org/10.1371/journal.pone.0043980 |