HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity

Histone deacetylases (HDACs) compact chromatin structure and repress gene transcription. In schizophrenia, clinical studies demonstrate that HDAC inhibitors are efficacious when given in combination with atypical antipsychotics. However, the molecular mechanism that integrates a better response to a...

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Detalles Bibliográficos
Autores principales: Kurita, Mitsumasa, Holloway, Terrell, García-Bea, Aintzane, Kozlenkov, Alexey, Friedman, Allyson K., Moreno, José L., Heshmati, Mitra, Golden, Sam A., Kennedy, Pamela J., Takahashi, Nagahide, Dietz, David M., Mocci, Giuseppe, Gabilondo, Ane M., Hanks, James, Umali, Adrienne, Callado, Luis F., Gallitano, Amelia L., Neve, Rachael L., Shen, Li, Buxbaum, Joseph D., Han, Ming-Hu, Nestler, Eric J., Meana, J. Javier, Russo, Scott J., González-Maeso, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431440/
https://www.ncbi.nlm.nih.gov/pubmed/22864611
http://dx.doi.org/10.1038/nn.3181

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431440/
https://www.ncbi.nlm.nih.gov/pubmed/22864611
http://dx.doi.org/10.1038/nn.3181

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