Cargando…

HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity

Histone deacetylases (HDACs) compact chromatin structure and repress gene transcription. In schizophrenia, clinical studies demonstrate that HDAC inhibitors are efficacious when given in combination with atypical antipsychotics. However, the molecular mechanism that integrates a better response to a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kurita, Mitsumasa, Holloway, Terrell, García-Bea, Aintzane, Kozlenkov, Alexey, Friedman, Allyson K., Moreno, José L., Heshmati, Mitra, Golden, Sam A., Kennedy, Pamela J., Takahashi, Nagahide, Dietz, David M., Mocci, Giuseppe, Gabilondo, Ane M., Hanks, James, Umali, Adrienne, Callado, Luis F., Gallitano, Amelia L., Neve, Rachael L., Shen, Li, Buxbaum, Joseph D., Han, Ming-Hu, Nestler, Eric J., Meana, J. Javier, Russo, Scott J., González-Maeso, Javier
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431440/ https://www.ncbi.nlm.nih.gov/pubmed/22864611 http://dx.doi.org/10.1038/nn.3181

Ejemplares similares

A group II metabotropic glutamate receptor 3 (mGlu3, GRM3) isoform implicated in schizophrenia interacts with canonical mGlu3 and reduces ligand binding
por: García-Bea, Aintzane, et al.
Publicado: (2017)

Opposite alterations of 5HT(2A) receptor brain density in subjects with schizophrenia: relevance of radiotracers pharmacological profile
por: Diez-Alarcia, Rebeca, et al.
Publicado: (2021)

Characterization of dopamine D(2) receptor coupling to G proteins in postmortem brain of subjects with schizophrenia
por: Egusquiza, Iker, et al.
Publicado: (2021)

Glucocorticoid receptor dysregulation underlies 5-HT(2A)R-dependent synaptic and behavioral deficits in a mouse neurodevelopmental disorder model
por: Saunders, Justin M., et al.
Publicado: (2022)

Group II Metabotropic Glutamate Receptors as Targets for Novel Antipsychotic Drugs
por: Muguruza, Carolina, et al.
Publicado: (2016)

Metabotropic glutamate receptor 3 (mGlu3; mGluR3; GRM3) in schizophrenia: Antibody characterisation and a semi-quantitative western blot study
por: García-Bea, Aintzane, et al.
Publicado: (2016)

Structural insights into dimerization and activation of the mGlu2–mGlu3 and mGlu2–mGlu4 heterodimers
por: Wang, Xinwei, et al.
Publicado: (2023)

Schizophrenia and depression, two poles of endocannabinoid system deregulation
por: Rodríguez-Muñoz, María, et al.
Publicado: (2017)

mGlu2 metabotropic glutamate receptors restrain inflammatory pain and mediate the analgesic activity of dual mGlu2/mGlu3 receptor agonists
por: Zammataro, Magda, et al.
Publicado: (2011)

Intracellular inflammatory and antioxidant pathways in postmortem frontal cortex of subjects with major depression: effect of antidepressants
por: Martín-Hernández, David, et al.
Publicado: (2018)

Emotional Impairment and Persistent Upregulation of mGlu(5) Receptor following Morphine Abstinence: Implications of an mGlu(5)-MOPr Interaction
por: Zanos, Panos, et al.
Publicado: (2016)

Decreased striatal dopamine in group II metabotropic glutamate receptor (mGlu2/mGlu3) double knockout mice
por: Lane, Tracy A, et al.
Publicado: (2013)

Allosteric Modulators for mGlu Receptors
por: Gasparini, F, et al.
Publicado: (2007)

Ribosomal Protein S6 Hypofunction in Postmortem Human Brain Links mTORC1-Dependent Signaling and Schizophrenia
por: Ibarra-Lecue, Inés, et al.
Publicado: (2020)

S182. HISTONE H3 AND H4 POST-TRANSLATIONAL REGULATION IN SCHIZOPHRENIA POSTMORTEM BRAIN: EFFECT OF ANTIPSYCHOTIC TREATMENT
por: Martínez-Peula, Oihane, et al.
Publicado: (2020)

mGlu5 Receptor Functional Interactions and Addiction
por: Brown, Robyn M., et al.
Publicado: (2012)

mGlu(5) Positive Allosteric Modulators Facilitate Long-Term Potentiation via Disinhibition Mediated by mGlu(5)-Endocannabinoid Signaling
por: Xiang, Zixiu, et al.
Publicado: (2019)

Chronic cannabis promotes pro-hallucinogenic signaling of 5-HT2A receptors through Akt/mTOR pathway
por: Ibarra-Lecue, Inés, et al.
Publicado: (2018)

Droplet-based bisulfite sequencing for high-throughput profiling of single-cell DNA methylomes
por: Zhang, Qiang, et al.
Publicado: (2023)

Droplet-based bisulfite sequencing for high-throughput profiling of single-cell DNA methylomes
por: Zhang, Qiang, et al.
Publicado: (2023)

Regulation and functional consequences of mGlu(4) RNA editing
por: Hofmann, Christopher S., et al.
Publicado: (2021)

Dissociable roles of mGlu5 and dopamine receptors in the rewarding and sensitizing properties of morphine and cocaine
por: Veeneman, M. M. J., et al.
Publicado: (2010)

Differential activity of mGlu(7) allosteric modulators provides evidence for mGlu(7/8) heterodimers at hippocampal Schaffer collateral-CA1 synapses
por: Lin, Xin, et al.
Publicado: (2022)

mGlu1 Receptors Monopolize the Synaptic Control of Cerebellar Purkinje Cells by Epigenetically Down-Regulating mGlu5 Receptors
por: Notartomaso, Serena, et al.
Publicado: (2018)

Altered Short-Term Synaptic Plasticity in Mice Lacking the Metabotropic Glutamate Receptor mGlu7
por: Bushell, Trevor J., et al.
Publicado: (2002)

43.1 GENETIC INSIGHTS LEAD TO DISCOVERY OF SELECTIVE ACTIVATORS OF MGLU1 AND MGLU3 METABOTROPIC GLUTAMATE RECEPTORS AS POTENTIAL TREATMENTS FOR SCHIZOPHRENIA
por: Conn, P Jeffrey, et al.
Publicado: (2018)

Differential brain ADRA2A and ADRA2C gene expression and epigenetic regulation in schizophrenia. Effect of antipsychotic drug treatment
por: Brocos-Mosquera, Iria, et al.
Publicado: (2021)

Deletion of Metabotropic Glutamate Receptors 2 and 3 (mGlu2 & mGlu3) in Mice Disrupts Sleep and Wheel-Running Activity, and Increases the Sensitivity of the Circadian System to Light
por: Pritchett, David, et al.
Publicado: (2015)

Discovery of a Novel Chemical Class of mGlu(5) Allosteric Ligands with Distinct Modes of Pharmacology
por: Hammond, Alexis S., et al.
Publicado: (2010)

Neurobiological Insights from mGlu Receptor Allosteric Modulation
por: O’Brien, Daniel E, et al.
Publicado: (2015)

Exploring the Activation Mechanism of the mGlu5 Transmembrane Domain
por: Lans, Isaias, et al.
Publicado: (2020)

Activation of mGlu3 Receptors Stimulates the Production of GDNF in Striatal Neurons
por: Battaglia, Giuseppe, et al.
Publicado: (2009)

Fractionation of Spatial Memory in GRM2/3 (mGlu2/mGlu3) Double Knockout Mice Reveals a Role for Group II Metabotropic Glutamate Receptors at the Interface Between Arousal and Cognition
por: Lyon, Louisa, et al.
Publicado: (2011)

Epigenetic regulation of synaptic remodeling in stress disorders
por: Golden, Sam A., et al.
Publicado: (2013)

Function of mGlu1 receptors in the modulation of nociceptive processing in the thalamus()
por: Salt, T.E., et al.
Publicado: (2014)

Structural insights into the activation initiation of full-length mGlu1
por: Zhang, Jinyi, et al.
Publicado: (2020)

mGlu2 mechanism-based interventions to treat alcohol relapse
por: Vengeliene, Valentina, et al.
Publicado: (2022)

The role of thalamic group II mGlu receptors in health and disease
por: Copeland, Caroline S., et al.
Publicado: (2022)

Tangrams: a simple visual tool for communicating the complexities of professionalism
por: Neve, Hilary, et al.
Publicado: (2022)

Interactive effects of mGlu5 and 5-HT(2A) receptors on locomotor activity in mice
por: Halberstadt, Adam L., et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_r6a35rdr8qti4qlq9vr28t9p4v