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Predicting cell-type–specific gene expression from regions of open chromatin

Complex patterns of cell-type–specific gene expression are thought to be achieved by combinatorial binding of transcription factors (TFs) to sequence elements in regulatory regions. Predicting cell-type–specific expression in mammals has been hindered by the oftentimes unknown location of distal reg...

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Detalles Bibliográficos
Autores principales: Natarajan, Anirudh, Yardımcı, Galip Gürkan, Sheffield, Nathan C., Crawford, Gregory E., Ohler, Uwe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431488/
https://www.ncbi.nlm.nih.gov/pubmed/22955983
http://dx.doi.org/10.1101/gr.135129.111