Synthesis of Triptorelin Lactate Catalyzed by Lipase in Organic Media

Triptorelin lactate was successfully synthesized by porcine pancreatic lipase (PPL) in organic solvents. The effects of acyl donor, substrate ratio, organic solvent, temperature, and water activity were investigated. Under the optimum conditions, a yield of 30% for its ester could be achieved in the...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhuang, Hong, Wang, Zhi, Wang, Jiaxin, Zhang, Hong, Xun, Erna, Chen, Ge, Yue, Hong, Tang, Ning, Wang, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431840/
https://www.ncbi.nlm.nih.gov/pubmed/22949842
http://dx.doi.org/10.3390/ijms13089971
_version_ 1782242113319075840
author Zhuang, Hong
Wang, Zhi
Wang, Jiaxin
Zhang, Hong
Xun, Erna
Chen, Ge
Yue, Hong
Tang, Ning
Wang, Lei
author_facet Zhuang, Hong
Wang, Zhi
Wang, Jiaxin
Zhang, Hong
Xun, Erna
Chen, Ge
Yue, Hong
Tang, Ning
Wang, Lei
author_sort Zhuang, Hong
collection PubMed
description Triptorelin lactate was successfully synthesized by porcine pancreatic lipase (PPL) in organic solvents. The effects of acyl donor, substrate ratio, organic solvent, temperature, and water activity were investigated. Under the optimum conditions, a yield of 30% for its ester could be achieved in the reaction for about 48 h.
format Online
Article
Text
id pubmed-3431840
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Molecular Diversity Preservation International (MDPI)
record_format MEDLINE/PubMed
spelling pubmed-34318402012-09-04 Synthesis of Triptorelin Lactate Catalyzed by Lipase in Organic Media Zhuang, Hong Wang, Zhi Wang, Jiaxin Zhang, Hong Xun, Erna Chen, Ge Yue, Hong Tang, Ning Wang, Lei Int J Mol Sci Article Triptorelin lactate was successfully synthesized by porcine pancreatic lipase (PPL) in organic solvents. The effects of acyl donor, substrate ratio, organic solvent, temperature, and water activity were investigated. Under the optimum conditions, a yield of 30% for its ester could be achieved in the reaction for about 48 h. Molecular Diversity Preservation International (MDPI) 2012-08-10 /pmc/articles/PMC3431840/ /pubmed/22949842 http://dx.doi.org/10.3390/ijms13089971 Text en © 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Zhuang, Hong
Wang, Zhi
Wang, Jiaxin
Zhang, Hong
Xun, Erna
Chen, Ge
Yue, Hong
Tang, Ning
Wang, Lei
Synthesis of Triptorelin Lactate Catalyzed by Lipase in Organic Media
title Synthesis of Triptorelin Lactate Catalyzed by Lipase in Organic Media
title_full Synthesis of Triptorelin Lactate Catalyzed by Lipase in Organic Media
title_fullStr Synthesis of Triptorelin Lactate Catalyzed by Lipase in Organic Media
title_full_unstemmed Synthesis of Triptorelin Lactate Catalyzed by Lipase in Organic Media
title_short Synthesis of Triptorelin Lactate Catalyzed by Lipase in Organic Media
title_sort synthesis of triptorelin lactate catalyzed by lipase in organic media
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431840/
https://www.ncbi.nlm.nih.gov/pubmed/22949842
http://dx.doi.org/10.3390/ijms13089971
work_keys_str_mv AT zhuanghong synthesisoftriptorelinlactatecatalyzedbylipaseinorganicmedia
AT wangzhi synthesisoftriptorelinlactatecatalyzedbylipaseinorganicmedia
AT wangjiaxin synthesisoftriptorelinlactatecatalyzedbylipaseinorganicmedia
AT zhanghong synthesisoftriptorelinlactatecatalyzedbylipaseinorganicmedia
AT xunerna synthesisoftriptorelinlactatecatalyzedbylipaseinorganicmedia
AT chenge synthesisoftriptorelinlactatecatalyzedbylipaseinorganicmedia
AT yuehong synthesisoftriptorelinlactatecatalyzedbylipaseinorganicmedia
AT tangning synthesisoftriptorelinlactatecatalyzedbylipaseinorganicmedia
AT wanglei synthesisoftriptorelinlactatecatalyzedbylipaseinorganicmedia

Ejemplares similares