SHP-1 Phosphatase Is a Critical Regulator in Preventing Natural Killer Cell Self-Killing

Balance of signals generated from the engaged activating and inhibitory surface receptors regulates mature NK cell activities. The inhibitory receptors signal through immunoreceptor tyrosine based inhibitory motifs (ITIM), and recruit phosphatases such as SHP-1 to inhibit NK cell activation. To dire...

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Detalles Bibliográficos
Autores principales: Mahmood, Sajid, Kanwar, Namita, Tran, Jimmy, Zhang, Man-li, Kung, Sam K. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432062/
https://www.ncbi.nlm.nih.gov/pubmed/22952938
http://dx.doi.org/10.1371/journal.pone.0044244

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432062/
https://www.ncbi.nlm.nih.gov/pubmed/22952938
http://dx.doi.org/10.1371/journal.pone.0044244

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