Stapled BH3 Peptides against MCL-1: Mechanism and Design Using Atomistic Simulations

Atomistic simulations of a set of stapled alpha helical peptides derived from the BH3 helix of MCL-1 (Stewart et al. (2010) Nat Chem Biol 6: 595–601) complexed to a fragment (residues 172–320) of MCL-1 revealed that the highest affinity is achieved when the staples engage the surface of MCL-1 as has...

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Detalles Bibliográficos
Autores principales: Joseph, Thomas L., Lane, David P., Verma, Chandra S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432064/
https://www.ncbi.nlm.nih.gov/pubmed/22952838
http://dx.doi.org/10.1371/journal.pone.0043985

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432064/
https://www.ncbi.nlm.nih.gov/pubmed/22952838
http://dx.doi.org/10.1371/journal.pone.0043985

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