Evaluation of a Novel Hexavalent Humanized Anti-IGF-1R Antibody and Its Bivalent Parental IgG in Diverse Cancer Cell Lines

A major mechanism of monoclonal antibodies that selectively target the insulin-like growth factor type 1 receptor (IGF-1R) to inhibit tumor growth is by downregulating the receptor, regardless whether they are capable (antagonistic) or incapable (agonistic) of blocking the binding of cognate ligands...

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Detalles Bibliográficos
Autores principales: Chang, Chien-Hsing, Wang, Yang, Trisal, Preeti, Li, Rongxiu, Rossi, Diane L., Nair, Anju, Gupta, Pankaj, Losman, Michele, Cardillo, Thomas M., Rossi, Edmund A., Goldenberg, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432068/
https://www.ncbi.nlm.nih.gov/pubmed/22952934
http://dx.doi.org/10.1371/journal.pone.0044235

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432068/
https://www.ncbi.nlm.nih.gov/pubmed/22952934
http://dx.doi.org/10.1371/journal.pone.0044235

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