An Antitubulin Agent BCFMT Inhibits Proliferation of Cancer Cells and Induces Cell Death by Inhibiting Microtubule Dynamics

Using cell based screening assay, we identified a novel anti-tubulin agent (Z)-5-((5-(4-bromo-3-chlorophenyl)furan-2-yl)methylene)-2-thioxothiazolidin-4-one (BCFMT) that inhibited proliferation of human cervical carcinoma (HeLa) (IC(50), 7.2±1.8 µM), human breast adenocarcinoma (MCF-7) (IC(50), 10.0...

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Detalles Bibliográficos
Autores principales: Rai, Ankit, Surolia, Avadhesha, Panda, Dulal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432122/
https://www.ncbi.nlm.nih.gov/pubmed/22952952
http://dx.doi.org/10.1371/journal.pone.0044311

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432122/
https://www.ncbi.nlm.nih.gov/pubmed/22952952
http://dx.doi.org/10.1371/journal.pone.0044311

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