Selective overexpression of Comt in prefrontal cortex rescues schizophrenia-like phenotypes in a mouse model of 22q11 deletion syndrome

The 22q11.2 microdeletion is one of the highest genetic risk factors for schizophrenia. It is not well understood which interactions of deleted genes in 22q11.2 regions are responsible for the pathogenesis of schizophrenia, but catechol-O-methytransferase (COMT) is among the candidates. Df1/+ mice a...

Descripción completa

Detalles Bibliográficos
Autores principales: Kimoto, S, Muraki, K, Toritsuka, M, Mugikura, S, Kajiwara, K, Kishimoto, T, Illingworth, E, Tanigaki, K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432186/
https://www.ncbi.nlm.nih.gov/pubmed/22872161
http://dx.doi.org/10.1038/tp.2012.70

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432186/
https://www.ncbi.nlm.nih.gov/pubmed/22872161
http://dx.doi.org/10.1038/tp.2012.70

Ejemplares similares