Distant residues mediate picomolar binding affinity of a protein cofactor

Numerous proteins require cofactors to be active. Computer simulations suggest that cooperative interaction networks achieve optimal cofactor binding. There is a need for the experimental identification of the residues crucial for stabilizing these networks and thus for cofactor binding. Here we inv...

Descripción completa

Detalles Bibliográficos
Autores principales: Bollen, Yves J.M., Westphal, Adrie H., Lindhoud, Simon, van Berkel, Willem J.H., van Mierlo, Carlo P.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432467/
https://www.ncbi.nlm.nih.gov/pubmed/22910356
http://dx.doi.org/10.1038/ncomms2010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432467/
https://www.ncbi.nlm.nih.gov/pubmed/22910356
http://dx.doi.org/10.1038/ncomms2010

Ejemplares similares