Crystallographic Study of Novel Transthyretin Ligands Exhibiting Negative-Cooperativity between Two Thyroxine Binding Sites

BACKGROUND: Transthyretin (TTR) is a homotetrameric serum and cerebrospinal fluid protein that transports thyroxine (T4) and retinol by binding to retinol binding protein. Rate-limiting tetramer dissociation and rapid monomer misfolding and disassembly of TTR lead to amyloid fibril formation in diff...

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Detalles Bibliográficos
Autores principales: Tomar, Divya, Khan, Tarique, Singh, Rajiv Ranjan, Mishra, Satyendra, Gupta, Sarika, Surolia, Avadhesha, Salunke, Dinakar M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433419/
https://www.ncbi.nlm.nih.gov/pubmed/22973437
http://dx.doi.org/10.1371/journal.pone.0043522

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433419/
https://www.ncbi.nlm.nih.gov/pubmed/22973437
http://dx.doi.org/10.1371/journal.pone.0043522

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