Toll-Like Receptor 4 and High-Mobility Group Box 1 Are Critical Mediators of Tissue Injury and Survival in a Mouse Model for Heatstroke

The molecular mechanisms that initiate the inflammatory response in heatstroke and their relation with tissue injury and lethality are not fully elucidated. We examined whether endogenous ligands released by damaged/stressed cells such as high-mobility group box 1 (HMGB1) signaling through Toll-like...

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Detalles Bibliográficos
Autores principales: Dehbi, Mohammed, Uzzaman, Taher, Baturcam, Engin, Eldali, Abdelmoneim, Ventura, Wilhelmina, Bouchama, Abderrezak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433483/
https://www.ncbi.nlm.nih.gov/pubmed/22962600
http://dx.doi.org/10.1371/journal.pone.0044100

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433483/
https://www.ncbi.nlm.nih.gov/pubmed/22962600
http://dx.doi.org/10.1371/journal.pone.0044100

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