Impact of transcription factor 7-like 2 (TCF7L2) on pancreatic islet function and morphology in mice and men

Common genetic variations in the gene encoding transcription factor 7-like 2 (TCF7L2) reveal the strongest association with type 2-diabetes known to date. These lead to impaired insulin production and output, but the mechanisms of disease remain incompletely known. In this issue of Diabetologia, two...

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Detalles Bibliográficos
Autor principal: Renström, E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2012
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433659/
https://www.ncbi.nlm.nih.gov/pubmed/22864463
http://dx.doi.org/10.1007/s00125-012-2659-1
Descripción
Sumario:Common genetic variations in the gene encoding transcription factor 7-like 2 (TCF7L2) reveal the strongest association with type 2-diabetes known to date. These lead to impaired insulin production and output, but the mechanisms of disease remain incompletely known. In this issue of Diabetologia, two publications provide new insights into TCF7L2-dependent diabetes.

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