Impact of transcription factor 7-like 2 (TCF7L2) on pancreatic islet function and morphology in mice and men

Common genetic variations in the gene encoding transcription factor 7-like 2 (TCF7L2) reveal the strongest association with type 2-diabetes known to date. These lead to impaired insulin production and output, but the mechanisms of disease remain incompletely known. In this issue of Diabetologia, two...

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Detalles Bibliográficos
Autor principal: Renström, E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2012
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433659/
https://www.ncbi.nlm.nih.gov/pubmed/22864463
http://dx.doi.org/10.1007/s00125-012-2659-1
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author Renström, E.
author_facet Renström, E.
author_sort Renström, E.
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description Common genetic variations in the gene encoding transcription factor 7-like 2 (TCF7L2) reveal the strongest association with type 2-diabetes known to date. These lead to impaired insulin production and output, but the mechanisms of disease remain incompletely known. In this issue of Diabetologia, two publications provide new insights into TCF7L2-dependent diabetes.
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spelling pubmed-34336592012-09-20 Impact of transcription factor 7-like 2 (TCF7L2) on pancreatic islet function and morphology in mice and men Renström, E. Diabetologia Commentary Common genetic variations in the gene encoding transcription factor 7-like 2 (TCF7L2) reveal the strongest association with type 2-diabetes known to date. These lead to impaired insulin production and output, but the mechanisms of disease remain incompletely known. In this issue of Diabetologia, two publications provide new insights into TCF7L2-dependent diabetes. Springer-Verlag 2012-08-05 2012 /pmc/articles/PMC3433659/ /pubmed/22864463 http://dx.doi.org/10.1007/s00125-012-2659-1 Text en © The Author(s) 2012 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Commentary
Renström, E.
Impact of transcription factor 7-like 2 (TCF7L2) on pancreatic islet function and morphology in mice and men
title Impact of transcription factor 7-like 2 (TCF7L2) on pancreatic islet function and morphology in mice and men
title_full Impact of transcription factor 7-like 2 (TCF7L2) on pancreatic islet function and morphology in mice and men
title_fullStr Impact of transcription factor 7-like 2 (TCF7L2) on pancreatic islet function and morphology in mice and men
title_full_unstemmed Impact of transcription factor 7-like 2 (TCF7L2) on pancreatic islet function and morphology in mice and men
title_short Impact of transcription factor 7-like 2 (TCF7L2) on pancreatic islet function and morphology in mice and men
title_sort impact of transcription factor 7-like 2 (tcf7l2) on pancreatic islet function and morphology in mice and men
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433659/
https://www.ncbi.nlm.nih.gov/pubmed/22864463
http://dx.doi.org/10.1007/s00125-012-2659-1
work_keys_str_mv AT renstrome impactoftranscriptionfactor7like2tcf7l2onpancreaticisletfunctionandmorphologyinmiceandmen

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