Stat5 Signaling Specifies Basal versus Stress Erythropoietic Responses through Distinct Binary and Graded Dynamic Modalities

Erythropoietin (Epo)-induced Stat5 phosphorylation (p-Stat5) is essential for both basal erythropoiesis and for its acceleration during hypoxic stress. A key challenge lies in understanding how Stat5 signaling elicits distinct functions during basal and stress erythropoiesis. Here we asked whether t...

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Detalles Bibliográficos
Autores principales: Porpiglia, Ermelinda, Hidalgo, Daniel, Koulnis, Miroslav, Tzafriri, Abraham R., Socolovsky, Merav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433736/
https://www.ncbi.nlm.nih.gov/pubmed/22969412
http://dx.doi.org/10.1371/journal.pbio.1001383

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433736/
https://www.ncbi.nlm.nih.gov/pubmed/22969412
http://dx.doi.org/10.1371/journal.pbio.1001383

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