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Methylation by Set9 modulates FoxO3 stability and transcriptional activity
The FoxO family of transcription factors plays an important role in longevity and tumor suppression by regulating the expression of a wide range of target genes. FoxO3 has recently been found to be associated with extreme longevity in humans and to regulate the homeostasis of adult stem cell pools i...
Autores principales: | Calnan, Daniel R., Webb, Ashley E., White, Jamie L., Stowe, Timothy R., Goswami, Tapasree, Shi, Xiaobing, Espejo, Alexsandra, Bedford, Mark T., Gozani, Or, Gygi, Steven P., Brunet, Anne |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433933/ https://www.ncbi.nlm.nih.gov/pubmed/22820736 |
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