Insights into Phosphate Cooperativity and Influence of Substrate Modifications on Binding and Catalysis of Hexameric Purine Nucleoside Phosphorylases

The hexameric purine nucleoside phosphorylase from Bacillus subtilis (BsPNP233) displays great potential to produce nucleoside analogues in industry and can be exploited in the development of new anti-tumor gene therapies. In order to provide structural basis for enzyme and substrates rational optim...

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Detalles Bibliográficos
Autores principales: de Giuseppe, Priscila O., Martins, Nadia H., Meza, Andreia N., dos Santos, Camila R., Pereira, Humberto D’Muniz, Murakami, Mario T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434127/
https://www.ncbi.nlm.nih.gov/pubmed/22957058
http://dx.doi.org/10.1371/journal.pone.0044282

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434127/
https://www.ncbi.nlm.nih.gov/pubmed/22957058
http://dx.doi.org/10.1371/journal.pone.0044282

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