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Reciprocal Regulation of Annexin A2 and EGFR with Her-2 in Her-2 Negative and Herceptin-Resistant Breast Cancer

Alternative survival pathways are commonly seen to be upregulated upon inhibition of receptor tyrosine kinases (RTK), including Her-2. It is established that treatment with Herceptin leads to selective overexpression and activation of epidermal growth factor receptor (EGFR) and Src which further con...

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Detalles Bibliográficos
Autores principales: Shetty, Praveenkumar K., Thamake, Sanjay I., Biswas, Swati, Johansson, Sonny L., Vishwanatha, Jamboor K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434131/
https://www.ncbi.nlm.nih.gov/pubmed/22957061
http://dx.doi.org/10.1371/journal.pone.0044299