Antibody Protection Reveals Extended Epitopes on the Human TSH Receptor

Stimulating, and some blocking, antibodies to the TSH receptor (TSHR) have conformation-dependent epitopes reported to involve primarily the leucine rich repeat region of the ectodomain (LRD). However, successful crystallization of TSHR residues 22–260 has omitted important extracellular non-LRD res...

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Detalles Bibliográficos
Autores principales: Latif, Rauf, Teixeira, Avelino, Michalek, Krzysztof, Ali, M. Rejwan, Schlesinger, Max, Baliram, Ramkumarie, Morshed, Syed A., Davies, Terry F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434159/
https://www.ncbi.nlm.nih.gov/pubmed/22957097
http://dx.doi.org/10.1371/journal.pone.0044669

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434159/
https://www.ncbi.nlm.nih.gov/pubmed/22957097
http://dx.doi.org/10.1371/journal.pone.0044669

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