Cargando…

Depletion of HDAC6 Enhances Cisplatin-Induced DNA Damage and Apoptosis in Non-Small Cell Lung Cancer Cells

Histone deacetylase inhibitors (HDACi) are promising therapeutic agents which are currently used in combination with chemotherapeutic agents in clinical trials for cancer treatment including non-small cell lung cancer (NSCLC). However, the mechanisms underlying their anti-tumor activities remain elu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Lei, Xiang, Shengyan, Williams, Kendra A., Dong, Huiqin, Bai, Wenlong, Nicosia, Santo V., Khochbin, Saadi, Bepler, Gerold, Zhang, Xiaohong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434198/ https://www.ncbi.nlm.nih.gov/pubmed/22957056 http://dx.doi.org/10.1371/journal.pone.0044265

Ejemplares similares

HDAC6 Regulates Radiosensitivity of Non-Small Cell Lung Cancer by Promoting Degradation of Chk1
por: Moses, Niko, et al.
Publicado: (2020)

The USP10-HDAC6 axis confers cisplatin resistance in non-small cell lung cancer lacking wild-type p53
por: Hu, Chen, et al.
Publicado: (2020)

Implications of the USP10-HDAC6 axis in lung cancer - A path to precision medicine
por: Zhang, Xiaohong Mary, et al.
Publicado: (2016)

CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin
por: Wickström, Sara A, et al.
Publicado: (2010)

INHIBITION OF ANDROGEN RECEPTOR ACTIVITY BY HISTONE DEACETYLASE 4 THROUGH RECEPTOR SUMOYLATION
por: Yang, Yonghua, et al.
Publicado: (2011)

HDAC6 inhibitor WT161 induces apoptosis in retinoblastoma cells and synergistically interacts with cisplatin
por: Sun, Jun, et al.
Publicado: (2019)

HDAC6–ubiquitin interaction controls the duration of HSF1 activation after heat shock
por: Pernet, Lydia, et al.
Publicado: (2014)

A Method for Biomarker Directed Survival Prediction in Advanced Non-Small-Cell Lung Cancer Patients Treated with Carboplatin-Based Therapy
por: Chen, Wei, et al.
Publicado: (2013)

The HDAC Inhibitor, SAHA, Combined with Cisplatin Synergistically Induces Apoptosis in Alpha-fetoprotein-producing Hepatoid Adenocarcinoma Cells
por: Kyaw, Myat Tin Htwe, et al.
Publicado: (2019)

Implications of the HDAC6-ERK1 feed-forward loop in immunotherapy
por: Wu, Jheng-Yu, et al.
Publicado: (2018)

Identification of small molecule inhibitors of ERCC1-XPF that inhibit DNA repair and potentiate cisplatin efficacy in cancer cells
por: Arora, Sanjeevani, et al.
Publicado: (2016)

CIP2A depletion potentiates the chemosensitivity of cisplatin by inducing increased apoptosis in bladder cancer cells
por: Gao, Fengbin, et al.
Publicado: (2018)

Efficacy of HDAC Inhibitors Belinostat and Panobinostat against Cisplatin-Sensitive and Cisplatin-Resistant Testicular Germ Cell Tumors
por: Lobo, João, et al.
Publicado: (2020)

Modulation of the Ribonucleotide Reductase-Antimetabolite Drug Interaction in Cancer Cell Lines
por: Zhou, Jun, et al.
Publicado: (2010)

Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells
por: Rajendran, Praveen, et al.
Publicado: (2011)

When are the BET factors the most sensitive to bromodomain inhibitors?
por: Khochbin, Saadi
Publicado: (2013)

HDAC1 and HDAC2 Double Knockout Triggers Cell Apoptosis in Advanced Thyroid Cancer
por: Lin, Ching-Ling, et al.
Publicado: (2019)

Cisplatin-enriching cancer stem cells confer multidrug resistance in non-small cell lung cancer via enhancing TRIB1/HDAC activity
por: Wang, Lihui, et al.
Publicado: (2017)

Deacetylation of Histone H4 Accompanying Cardiomyogenesis is Weakened in HDAC1-Depleted ES Cells
por: Arcidiacono, Orazio Angelo, et al.
Publicado: (2018)

UHRF1 depletion and HDAC inhibition reactivate epigenetically silenced genes in colorectal cancer cells
por: Niinuma, Takeshi, et al.
Publicado: (2019)

Knockdown of HDAC1 expression suppresses invasion and induces apoptosis in glioma cells
por: Wang, Xiao-Qiang, et al.
Publicado: (2017)

Hesperidin ameliorates cisplatin induced hepatotoxicity and attenuates oxidative damage, cell apoptosis, and inflammation in rats
por: Aboraya, Dina M., et al.
Publicado: (2022)

MDC1 depletion promotes cisplatin induced cell death in cervical cancer cells
por: Singh, Neeru, et al.
Publicado: (2020)

Depletion of HDAC1, 7 and 8 by Histone Deacetylase Inhibition Confers Elimination of Pancreatic Cancer Stem Cells in Combination with Gemcitabine
por: Cai, Mao-Hua, et al.
Publicado: (2018)

Induction of Apoptosis and Autophagy in Breast Cancer Cells by a Novel HDAC8 Inhibitor
por: Chiu, Chang-Fang, et al.
Publicado: (2019)

Neural Differentiation in HDAC1-Depleted Cells Is Accompanied by Coilin Downregulation and the Accumulation of Cajal Bodies in Nucleoli
por: Krejčí, Jana, et al.
Publicado: (2017)

Autotaxin is induced by TSA through HDAC3 and HDAC7 inhibition and antagonizes the TSA-induced cell apoptosis
por: Li, Song, et al.
Publicado: (2011)

Priming with HDAC Inhibitors Sensitizes Ovarian Cancer Cells to Treatment with Cisplatin and HSP90 Inhibitors
por: Rodrigues Moita, Ana J., et al.
Publicado: (2020)

Glutathione depletion sensitizes cisplatin- and temozolomide-resistant glioma cells in vitro and in vivo
por: Rocha, C R R, et al.
Publicado: (2014)

Glutathione depletion sensitizes cisplatin- and temozolomide-resistant glioma cells in vitro and in vivo
por: Rocha, C R R, et al.
Publicado: (2015)

Combined HDAC1 and HDAC2 Depletion Promotes Retinal Ganglion Cell Survival After Injury Through Reduction of p53 Target Gene Expression
por: Lebrun-Julien, Frédéric, et al.
Publicado: (2015)

Histone Acylation beyond Acetylation: Terra Incognita in Chromatin Biology
por: Rousseaux, Sophie, et al.
Publicado: (2015)

Knockdown of Akt Sensitizes Osteosarcoma Cells to Apoptosis Induced by Cisplatin Treatment
por: Zhang, Guoyou, et al.
Publicado: (2011)

HDAC2 attenuates TRAIL-induced apoptosis of pancreatic cancer cells
por: Schüler, Susanne, et al.
Publicado: (2010)

Sensitivity of osteosarcoma cells to HDAC inhibitor AR-42 mediated apoptosis
por: Murahari, Sridhar, et al.
Publicado: (2017)

Peroxisomes protect lymphoma cells from HDAC inhibitor-mediated apoptosis
por: Dahabieh, Michael S, et al.
Publicado: (2017)

Ubiquitination and Degradation of Ribonucleotide Reductase M1 by the Polycomb Group Proteins RNF2 and Bmi1 and Cellular Response to Gemcitabine
por: Zhang, Yingtao, et al.
Publicado: (2014)

Chidamide induces apoptosis in DLBCL cells by suppressing the HDACs/STAT3/Bcl-2 pathway
por: Zhang, Hongwei, et al.
Publicado: (2021)

Class I-Histone Deacetylase (HDAC) Inhibition is Superior to pan-HDAC Inhibition in Modulating Cisplatin Potency in High Grade Serous Ovarian Cancer Cell Lines
por: Bandolik, Jan J., et al.
Publicado: (2019)

Depletion of senescent-like neuronal cells alleviates cisplatin-induced peripheral neuropathy in mice
por: Acklin, Scarlett, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_1rb9a51c34bgj92j55ivfogja4