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A Practical Simulation Method to Calculate Sample Size of Group Sequential Trials for Time-to-Event Data under Exponential and Weibull Distribution
Group sequential design has been widely applied in clinical trials in the past few decades. The sample size estimation is a vital concern of sponsors and investigators. Especially in the survival group sequential trials, it is a thorny question because of its ambiguous distributional form, censored...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434206/ https://www.ncbi.nlm.nih.gov/pubmed/22957040 http://dx.doi.org/10.1371/journal.pone.0044013 |