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Prolonged Action Potential and After depolarizations Are Not due to Changes in Potassium Currents in NOS3 Knockout Ventricular Myocytes
Ventricular myocytes deficient in endothelial nitric oxide synthase (NOS3(−/−)) exhibit prolonged action potential (AP) duration and enhanced spontaneous activity (early and delayed afterdepolarizations) during β-adrenergic (β-AR) stimulation. Studies have shown that nitric oxide is able to regulate...
Autores principales: | Wang, Honglan, Bonilla, Ingrid M., Huang, Xin, He, Quanhua, Kohr, Mark J., Carnes, Cynthia A., Ziolo, Mark T. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434404/ https://www.ncbi.nlm.nih.gov/pubmed/22970362 http://dx.doi.org/10.1155/2012/645721 |
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