Identification of binding pockets in protein structures using a knowledge-based potential derived from local structural similarities

BACKGROUND: The identification of ligand binding sites is a key task in the annotation of proteins with known structure but uncharacterized function. Here we describe a knowledge-based method exploiting the observation that unrelated binding sites share small structural motifs that bind the same che...

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Detalles Bibliográficos
Autores principales: Bianchi, Valerio, Gherardini, Pier Federico, Helmer-Citterich, Manuela, Ausiello, Gabriele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434446/
https://www.ncbi.nlm.nih.gov/pubmed/22536963
http://dx.doi.org/10.1186/1471-2105-13-S4-S17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434446/
https://www.ncbi.nlm.nih.gov/pubmed/22536963
http://dx.doi.org/10.1186/1471-2105-13-S4-S17

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