Apoptosis and autophagy have opposite roles on imatinib-induced K562 leukemia cell senescence

Imatinib, the anti-Abl tyrosine kinase inhibitor used as first-line therapy in chronic myeloid leukemia (CML), eliminates CML cells mainly by apoptosis and induces autophagy. Analysis of imatinib-treated K562 cells reveals a cell population with cell cycle arrest, p27 increase and senescence-associa...

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Detalles Bibliográficos
Autores principales: Drullion, C, Trégoat, C, Lagarde, V, Tan, S, Gioia, R, Priault, M, Djavaheri-Mergny, M, Brisson, A, Auberger, P, Mahon, F-X, Pasquet, J-M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434662/
https://www.ncbi.nlm.nih.gov/pubmed/22898871
http://dx.doi.org/10.1038/cddis.2012.111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434662/
https://www.ncbi.nlm.nih.gov/pubmed/22898871
http://dx.doi.org/10.1038/cddis.2012.111

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