Glucocorticoid resistance in chronic lymphocytic leukaemia is associated with a failure of upregulated Bim/Bcl-2 complexes to activate Bax and Bak

Glucocorticoids (GCs) represent an important component of modern treatment regimens for fludarabine-refractory or TP53-defective chronic lymphocytic leukemia (CLL). However, GC therapy is not effective in all patients. The molecular mechanisms responsible for GC-induced apoptosis and resistance were...

Descripción completa

Detalles Bibliográficos
Autores principales: Melarangi, T, Zhuang, J, Lin, K, Rockliffe, N, Bosanquet, A G, Oates, M, Slupsky, J R, Pettitt, A R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434667/
https://www.ncbi.nlm.nih.gov/pubmed/22898870
http://dx.doi.org/10.1038/cddis.2012.102

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434667/
https://www.ncbi.nlm.nih.gov/pubmed/22898870
http://dx.doi.org/10.1038/cddis.2012.102

Ejemplares similares