Cargando…

Transforming Growth Factor-Beta Promotes Rhinovirus Replication in Bronchial Epithelial Cells by Suppressing the Innate Immune Response

Rhinovirus (RV) infection is a major cause of asthma exacerbations which may be due to a deficient innate immune response in the bronchial epithelium. We hypothesized that the pleiotropic cytokine, TGF-β, influences interferon (IFN) production by primary bronchial epithelial cells (PBECs) following...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bedke, Nicole, Sammut, David, Green, Ben, Kehagia, Valia, Dennison, Patrick, Jenkins, Gisli, Tatler, Amanda, Howarth, Peter H., Holgate, Stephen T., Davies, Donna E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435262/ https://www.ncbi.nlm.nih.gov/pubmed/22970254 http://dx.doi.org/10.1371/journal.pone.0044580

Ejemplares similares

Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus
por: Wark, Peter A.B., et al.
Publicado: (2005)

Rhinovirus-16 Induced Release of IP-10 and IL-8 Is Augmented by Th2 Cytokines in a Pediatric Bronchial Epithelial Cell Model
por: Cakebread, Julie A., et al.
Publicado: (2014)

A MicroRNA Network Dysregulated in Asthma Controls IL-6 Production in Bronchial Epithelial Cells
por: Martinez-Nunez, Rocio T., et al.
Publicado: (2014)

Increased nuclear suppressor of cytokine signaling 1 in asthmatic bronchial epithelium suppresses rhinovirus induction of innate interferons
por: Gielen, Vera, et al.
Publicado: (2015)

Barrier Disrupting Effects of Alternaria Alternata Extract on Bronchial Epithelium from Asthmatic Donors
por: Leino, Marina S., et al.
Publicado: (2013)

Rhinovirus replication and innate immunity in highly differentiated human airway epithelial cells
por: Warner, Stephanie M., et al.
Publicado: (2019)

O20 - Human rhinovirus replication-dependent induction of micro-RNAs in human bronchial epithelial cells
por: Megremis, Spyridon, et al.
Publicado: (2014)

Co-ordinated Role of TLR3, RIG-I and MDA5 in the Innate Response to Rhinovirus in Bronchial Epithelium
por: Slater, Louise, et al.
Publicado: (2010)

Mechanical Strain Causes Adaptive Change in Bronchial Fibroblasts Enhancing Profibrotic and Inflammatory Responses
por: Manuyakorn, Wiparat, et al.
Publicado: (2016)

Cigarette Smoke Causes Caspase-Independent Apoptosis of Bronchial Epithelial Cells from Asthmatic Donors
por: Bucchieri, Fabio, et al.
Publicado: (2015)

Correction: Co-ordinated Role of TLR3, RIG-I and MDA5 in the Innate Response to Rhinovirus in Bronchial Epithelium
por: Slater, Louise, et al.
Publicado: (2012)

Rhinovirus and Innate Immune Function of Airway Epithelium
por: Ganjian, Haleh, et al.
Publicado: (2020)

Human rhinovirus infection of human bronchial epithelial cells results in migration of human bronchial fibroblast cells
por: Shelfoon, Christopher, et al.
Publicado: (2014)

COVID‐19 and pulmonary fibrosis: A potential role for lung epithelial cells and fibroblasts
por: John, Alison E., et al.
Publicado: (2021)

Mast cells are permissive for rhinovirus replication: potential implications for asthma exacerbations
por: Akoto, C., et al.
Publicado: (2017)

Quercetin inhibits rhinovirus replication in vitro and in vivo
por: Ganesan, Shyamala, et al.
Publicado: (2012)

IFN-γ–induced protein 10 is a novel biomarker of rhinovirus-induced asthma exacerbations
por: Wark, Peter A.B., et al.
Publicado: (2007)

Potentially Pathogenic Airway Bacteria and Neutrophilic Inflammation in Treatment Resistant Severe Asthma
por: Green, Benjamin J., et al.
Publicado: (2014)

Diesel exhaust increases EGFR and phosphorylated C-terminal Tyr 1173 in the bronchial epithelium
por: Pourazar, Jamshid, et al.
Publicado: (2008)

Characterising the Mechanism of Airway Smooth Muscle β(2) Adrenoceptor Desensitization by Rhinovirus Infected Bronchial Epithelial Cells
por: Van Ly, David, et al.
Publicado: (2013)

Rhinovirus infection induces cytotoxicity and delays wound healing in bronchial epithelial cells
por: Bossios, Apostolos, et al.
Publicado: (2005)

Bronchial mucosal inflammation and illness severity in response to experimental rhinovirus infection in COPD
por: Zhu, Jie, et al.
Publicado: (2020)

Imprinting of bronchial epithelial cells upon in vivo rhinovirus infection in people with asthma
por: Ravi, Abilash, et al.
Publicado: (2022)

Interference between rhinovirus and influenza A virus: a clinical data analysis and experimental infection study
por: Wu, Anchi, et al.
Publicado: (2020)

The Role of Interleukin-1 and Interleukin-18 in Pro-Inflammatory and Anti-Viral Responses to Rhinovirus in Primary Bronchial Epithelial Cells
por: Piper, Siân C., et al.
Publicado: (2013)

Interferon response of the cystic fibrosis bronchial epithelium to major and minor group rhinovirus infection
por: Schögler, Aline, et al.
Publicado: (2016)

Altered transcriptional and chromatin responses to rhinovirus in bronchial epithelial cells from adults with asthma
por: Helling, Britney A., et al.
Publicado: (2020)

Remodeling of bronchial epithelium caused by asthmatic inflammation affects its response to rhinovirus infection
por: Jakiela, Bogdan, et al.
Publicado: (2021)

In Vitro Effects of 5-Lipoxygenase Pathway Inhibition on Rhinovirus-Associated Bronchial Epithelial Inflammation
por: Spyridaki, Irini, et al.
Publicado: (2021)

Human rhinovirus promotes STING trafficking to replication organelles to promote viral replication
por: Triantafilou, Martha, et al.
Publicado: (2022)

Investigation of the Role of Protein Kinase D in Human Rhinovirus Replication
por: Guedán, Anabel, et al.
Publicado: (2017)

O04 - Effects of 5-lipoxygenase pathway inhibition on rhinovirus-associated bronchial epithelial inflammation
por: Spyridaki, Irini, et al.
Publicado: (2014)

Caffeine inhibits TGFβ activation in epithelial cells, interrupts fibroblast responses to TGFβ, and reduces established fibrosis in ex vivo precision-cut lung slices
por: Tatler, Amanda L, et al.
Publicado: (2016)

Effects of β (2) Agonists, Corticosteroids, and Novel Therapies on Rhinovirus-Induced Cytokine Release and Rhinovirus Replication in Primary Airway Fibroblasts
por: Van Ly, David, et al.
Publicado: (2011)

Innate Immune Responses by Respiratory Viruses, Including Rhinovirus, During Asthma Exacerbation
por: Nakagome, Kazuyuki, et al.
Publicado: (2022)

Rhinovirus Load Is High despite Preserved Interferon-β Response in Cystic Fibrosis Bronchial Epithelial Cells
por: Dauletbaev, Nurlan, et al.
Publicado: (2015)

Budesonide and formoterol effects on rhinovirus replication and epithelial cell cytokine responses
por: Bochkov, Yury A, et al.
Publicado: (2013)

Effects of Vitamin D on Airway Epithelial Cell Morphology and Rhinovirus Replication
por: Brockman-Schneider, Rebecca A., et al.
Publicado: (2014)

Dynamic innate immune response determines susceptibility to SARS-CoV-2 infection and early replication kinetics
por: Cheemarla, Nagarjuna R., et al.
Publicado: (2021)

Transforming growth factor beta1 targets estrogen receptor signaling in bronchial epithelial cells
por: Smith, L. Cody, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_5dlsm6bv9ttvscjralatrdq51k