Evaluation of OPEN Zinc Finger Nucleases for Direct Gene Targeting of the ROSA26 Locus in Mouse Embryos

Zinc finger nucleases (ZFNs) enable precise genome modification in a variety of organisms and cell types. Commercial ZFNs were reported to enhance gene targeting directly in mouse zygotes, whereas similar approaches using publicly available resources have not yet been described. Here we report preci...

Descripción completa

Detalles Bibliográficos
Autores principales: Hermann, Mario, Maeder, Morgan L., Rector, Kyle, Ruiz, Joseph, Becher, Burkhard, Bürki, Kurt, Khayter, Cyd, Aguzzi, Adriano, Joung, J. Keith, Buch, Thorsten, Pelczar, Pawel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435328/
https://www.ncbi.nlm.nih.gov/pubmed/22970113
http://dx.doi.org/10.1371/journal.pone.0041796

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435328/
https://www.ncbi.nlm.nih.gov/pubmed/22970113
http://dx.doi.org/10.1371/journal.pone.0041796

Ejemplares similares