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Exploring the Mechanism of Zanamivir Resistance in a Neuraminidase Mutant: A Molecular Dynamics Study

It is critical to understand the molecular basis of the drug resistance of influenza viruses to efficiently treat this infectious disease. Recently, H1N1 strains of influenza A carrying a mutation of Q136K in neuraminidase were found. The new strain showed a strong Zanamivir neutralization effect. I...

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Detalles Bibliográficos
Autores principales: Han, Nanyu, Liu, Xuewei, Mu, Yuguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435372/
https://www.ncbi.nlm.nih.gov/pubmed/22970161
http://dx.doi.org/10.1371/journal.pone.0044057